Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy.

Borohydrides / chemistry Boron / chemistry Boron Neutron Capture Therapy Cell Line, Tumor Cell Survival / drug effects Drug Design Glioblastoma / radiotherapy Humans Lipopeptides / chemistry Radiation-Sensitizing Agents / chemical synthesis Sulfhydryl Compounds / chemistry
antitumor therapy boron carriers boron neutron capture therapy membrane-permeable lipopeptides

Journal

ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013

Informations de publication

Date de publication:
17 04 2019
Historique:
received: 15 12 2018
revised: 23 01 2019
pubmed: 2 2 2019
medline: 9 1 2020
entrez: 2 2 2019
Statut: ppublish

Résumé

We developed new

Identifiants

DOI: 10.1002/cmdc.201800793 PMID: 30707500
pubmed: 30707500
doi: 10.1002/cmdc.201800793
doi:

Substances chimiques

Borohydrides 0
Lipopeptides 0
Radiation-Sensitizing Agents 0
Sulfhydryl Compounds 0
mercaptoundecahydrododecaborate 12294-22-3
Boron N9E3X5056Q

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

823-832

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Aoi Isono (A)

Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu-city, Gifu, 501-1196, Japan.

Mieko Tsuji (M)

Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu-city, Gifu, 501-1196, Japan.
ORCID: 0000-0003-2072-2118

Yu Sanada (Y)

Particle Radiation Biology, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.

Akari Matsushita (A)

Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu-city, Gifu, 501-1196, Japan.

Shinichiro Masunaga (S)

Particle Radiation Biology, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.

Tasuku Hirayama (T)

Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu-city, Gifu, 501-1196, Japan.
ORCID: 0000-0003-4541-7849

Hideko Nagasawa (H)

Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu-city, Gifu, 501-1196, Japan.
ORCID: 0000-0002-7662-0762

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Boranes › Tétrahydroborates › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Lipopeptides › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Design, Synthesis, and Evaluation of...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › Design, Synthesis, and Evaluation of...