The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis.
Chemosensation
PHOX2B
Respiration
Sleep Homeostasis
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
23
11
2018
accepted:
28
01
2019
pubmed:
2
2
2019
medline:
28
7
2020
entrez:
2
2
2019
Statut:
ppublish
Résumé
The embryonic PHOX2B-progenitor domain generates neuronal and glial cells which together are involved in chemosensory control of breathing and sleep homeostasis. Ablating PHOX2B-derived astrocytes significantly contributes to secondary hypoxic respiratory depression as well as abnormalities in sleep homeostasis. PHOX2B-derived astrocyte ablation results in axonal pathologies in the retrotrapezoid nucleus. We identify in mice a population of ∼800 retrotrapezoid nucleus (RTN) astrocytes derived from PHOX2B-positive, OLIG3-negative progenitor cells, that interact with PHOX2B-expressing RTN chemosensory neurons. PHOX2B-derived astrocyte ablation during early life results in adult-onset O
Identifiants
pubmed: 30707772
doi: 10.1113/JP277082
pmc: PMC6462490
doi:
Substances chimiques
Homeodomain Proteins
0
Phox2b protein, mouse
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2225-2251Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL132355
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Informations de copyright
© 2019 The Authors. The Journal of Physiology © 2019 The Physiological Society.
Références
J Physiol. 1999 Dec 15;521 Pt 3:679-90
pubmed: 10601498
Development. 2000 Apr;127(7):1349-58
pubmed: 10704382
Mol Cell Neurosci. 2000 Mar;15(3):235-43
pubmed: 10736201
Science. 1975 Jul 4;189(4196):55-8
pubmed: 1094539
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1004-8
pubmed: 10988121
Development. 2000 Dec;127(23):5191-201
pubmed: 11060244
J Neurosci. 2001 Feb 1;21(3):1076-85
pubmed: 11157094
J Neurosci. 2002 Jan 1;22(1):183-92
pubmed: 11756501
Curr Opin Genet Dev. 2002 Aug;12(4):435-40
pubmed: 12100889
Neuroscience. 2002;113(1):221-33
pubmed: 12123700
Nat Genet. 2003 Apr;33(4):459-61
pubmed: 12640453
Genes Dev. 2003 Mar 15;17(6):729-37
pubmed: 12651891
Neuroscience. 2003;119(4):913-8
pubmed: 12831851
Development. 2003 Dec;130(26):6635-42
pubmed: 14627719
Neuroscience. 2003;122(4):1107-13
pubmed: 14643776
Neuroscience. 2004;123(2):451-7
pubmed: 14698752
Am J Respir Crit Care Med. 2004 Jul 1;170(1):16-21
pubmed: 15105164
Development. 2004 Aug;131(15):3545-57
pubmed: 15262888
Nature. 2005 Jul 7;436(7047):108-11
pubmed: 16001070
Neuroscience. 2005;134(4):1377-90
pubmed: 16039802
Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1715-23
pubmed: 16109808
J Physiol. 2006 Apr 15;572(Pt 2):503-23
pubmed: 16455687
J Neurosci. 2006 Oct 4;26(40):10305-14
pubmed: 17021186
J Neurophysiol. 2007 Jan;97(1):837-48
pubmed: 17093123
Sleep. 2007 Aug;30(8):980-9
pubmed: 17702267
Autophagy. 2008 Jan;4(1):94-6
pubmed: 18000396
J Physiol. 2008 Jun 15;586(12):2975-91
pubmed: 18440993
J Neuropathol Exp Neurol. 2008 Dec;67(12):1166-86
pubmed: 19018240
Neuron. 2009 Jan 29;61(2):213-9
pubmed: 19186164
Am J Respir Crit Care Med. 2010 Mar 15;181(6):626-44
pubmed: 20208042
Neurology. 2010 Mar 16;74(11):919-23
pubmed: 20231669
J Neurosci. 2010 Mar 17;30(11):3947-58
pubmed: 20237265
Science. 2010 Jul 30;329(5991):571-5
pubmed: 20647426
J Neurosci. 2010 Sep 15;30(37):12466-73
pubmed: 20844141
Cell Stem Cell. 2011 Jun 3;8(6):663-75
pubmed: 21624811
J Neurosci. 2011 Sep 7;31(36):12880-8
pubmed: 21900566
Ann N Y Acad Sci. 1990;600:260-8; discussion 268-71
pubmed: 2252314
Science. 2012 Jul 20;337(6092):358-62
pubmed: 22745251
Int J Neurosci. 2013 Jul;123(7):439-43
pubmed: 23311713
Genesis. 2013 Jul;51(7):506-14
pubmed: 23592597
PLoS One. 2013 Sep 25;8(9):e75248
pubmed: 24086480
PLoS Genet. 2013;9(10):e1003845
pubmed: 24098148
Dev Biol. 2014 Jan 15;385(2):328-39
pubmed: 24184637
Exp Physiol. 2014 Mar;99(3):571-85
pubmed: 24363384
Nat Rev Neurosci. 2014 May;15(5):327-35
pubmed: 24739787
Nature. 2014 May 8;509(7499):189-94
pubmed: 24776795
Compr Physiol. 2014 Oct;4(4):1511-62
pubmed: 25428853
Cell Death Differ. 2015 Mar;22(3):398-407
pubmed: 25526091
Cold Spring Harb Perspect Biol. 2015 Feb 06;7(9):a020370
pubmed: 25663667
Neurochem Res. 2015 Dec;40(12):2386-93
pubmed: 25837670
Elife. 2015 Apr 13;4:null
pubmed: 25866925
J Cell Biol. 2015 May 11;209(3):377-86
pubmed: 25940348
Acta Neuropathol. 2015 Aug;130(2):171-83
pubmed: 25975378
J Physiol. 2015 Jul 15;593(14):3159-68
pubmed: 25981852
Brain Behav Immun. 2015 Nov;50:178-185
pubmed: 26144889
J Neurosci. 2015 Jul 22;35(29):10460-73
pubmed: 26203141
Physiology (Bethesda). 2015 Sep;30(5):340-8
pubmed: 26328879
J Comp Neurol. 2016 Apr 15;524(6):1259-69
pubmed: 26400711
Nat Neurosci. 2015 Nov;18(11):1539-1545
pubmed: 26505565
BMC Biol. 2016 Jul 08;14:57
pubmed: 27392568
Aging (Albany NY). 2016 Jul;8(7):1540-70
pubmed: 27425845
Neuron. 2017 Feb 8;93(3):587-605.e7
pubmed: 28132831
Psychiatry Investig. 2017 Mar;14(2):193-197
pubmed: 28326118
J Appl Physiol (1985). 2017 Nov 1;123(5):1344-1349
pubmed: 28522760
J Physiol. 2018 Jul;596(13):2521-2545
pubmed: 29667182
Cell Metab. 2018 Jul 3;28(1):118-129.e5
pubmed: 29805100
J Comp Neurol. 2018 Sep 1;526(13):2032-2047
pubmed: 29888789
Ergeb Physiol. 1972;64:166-307
pubmed: 4403272
Respir Physiol. 1973 Jan;17(1):32-44
pubmed: 4688286
Respir Physiol. 1970 Oct;10(3):384-95
pubmed: 5476156
J Neurosci. 1981 Aug;1(8):876-86
pubmed: 7346592
Science. 1994 Feb 4;263(5147):689-92
pubmed: 8303279
J Neurosci. 1996 Dec 1;16(23):7649-60
pubmed: 8922421
Development. 1997 Oct;124(20):4065-75
pubmed: 9374403