α-Lipoic Acid Reduces Iron-induced Toxicity and Oxidative Stress in a Model of Iron Overload.
Animals
Autophagy
/ drug effects
Cell Line
Disease Models, Animal
Ferric Compounds
/ adverse effects
Glutathione
/ metabolism
Heme Oxygenase-1
/ genetics
Humans
Iron Chelating Agents
/ administration & dosage
Iron Overload
/ chemically induced
Oxidative Stress
/ drug effects
Quaternary Ammonium Compounds
/ adverse effects
Reactive Oxygen Species
/ metabolism
Superoxide Dismutase
/ genetics
Thioctic Acid
/ administration & dosage
Zebrafish
alpha lipoic acid
iron
oxidative stress
toxicity
zebrafish
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jan 2019
31 Jan 2019
Historique:
received:
08
01
2019
revised:
22
01
2019
accepted:
24
01
2019
entrez:
3
2
2019
pubmed:
3
2
2019
medline:
19
6
2019
Statut:
epublish
Résumé
Iron toxicity is associated with organ injury and has been reported in various clinical conditions, such as hemochromatosis, thalassemia major, and myelodysplastic syndromes. Therefore, iron chelation therapy represents a pivotal therapy for these patients during their lifetime. The aim of the present study was to assess the iron chelating properties of α-lipoic acid (ALA) and how such an effect impacts on iron overload mediated toxicity. Human mesenchymal stem cells (HS-5) and animals (zebrafish,
Identifiants
pubmed: 30708965
pii: ijms20030609
doi: 10.3390/ijms20030609
pmc: PMC6387298
pii:
doi:
Substances chimiques
Ferric Compounds
0
Iron Chelating Agents
0
Quaternary Ammonium Compounds
0
Reactive Oxygen Species
0
Thioctic Acid
73Y7P0K73Y
Heme Oxygenase-1
EC 1.14.14.18
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
ferric ammonium citrate
UVP74NG1C5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Catania
ID : Fir 2018
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