The Link Between Inflammaging and Degenerative Joint Diseases.
chondrosenescence
inflammaging
osteoarthritis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Jan 2019
31 Jan 2019
Historique:
received:
24
12
2018
revised:
21
01
2019
accepted:
29
01
2019
entrez:
3
2
2019
pubmed:
3
2
2019
medline:
19
6
2019
Statut:
epublish
Résumé
Aging is an inevitable process in the human body that is associated with a multitude of systemic and localized changes. All these conditions have a common pathogenic mechanism characterized by the presence of a low-grade proinflammatory status. Inflammaging refers to all the processes that contribute to the occurrence of various diseases associated with aging such as frailty, atherosclerosis, Alzheimer's disease, sarcopenia, type 2 diabetes, or osteoarthritis. Inflammaging is systemic, chronic, and asymptomatic. Osteoarthritis and many age-related degenerative joint diseases are correlated with aging mechanisms such as the presence of an inflammatory microenvironment and the impaired link between inflammasomes and autophagy. There is a close relationship between chondrocyte activity and local articular environment changes due to cell senescence, followed by secretion of inflammatory mediators. In addition, systemic inflammaging can lead to cartilage destruction, pain, disability, and an impaired quality of life. The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.
Identifiants
pubmed: 30708978
pii: ijms20030614
doi: 10.3390/ijms20030614
pmc: PMC6386892
pii:
doi:
Substances chimiques
Inflammasomes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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