Biomarkers in Fetomaternal Tolerance.
Biomarkers
/ blood
Dendritic Cells
/ immunology
Female
Histocompatibility, Maternal-Fetal
/ immunology
Humans
Killer Cells, Natural
/ immunology
Macrophages
/ immunology
Maternal-Fetal Exchange
Models, Immunological
Myeloid-Derived Suppressor Cells
/ immunology
Pregnancy
Transplantation Tolerance
/ immunology
Allograft
Biomarkers
Bregs
Fetomaternal tolerance
MDSCs
Tregs
miRNA
Journal
Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
entrez:
3
2
2019
pubmed:
3
2
2019
medline:
10
9
2019
Statut:
ppublish
Résumé
Multiple mechanisms of tolerance operate in the immune cross-talk at the fetomaternal interface, contributing to successful pregnancy outcome. The cross-talk includes interaction between various cell subsets and between cytokines and molecules of the endocrine system. A depiction of how all these components interact with each other and contribute to tolerance of the fetus is not clearly understood. Dysregulation in one or more of these mechanisms leads to fetal loss. Few effective biomarkers are available that can safely predict fetal loss. This review discusses some potential biomarkers that can predict failure of tolerance at the fetomaternal interface.
Identifiants
pubmed: 30709502
pii: S0272-2712(18)31209-5
doi: 10.1016/j.cll.2018.11.002
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-156Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.