The genetics and epigenetics of Neonatal Abstinence Syndrome.

Analgesics, Opioid / adverse effects Epigenesis, Genetic Humans Infant, Newborn Neonatal Abstinence Syndrome / genetics Receptors, Opioid, mu / genetics
Epigenetics Genetics Neonatal Abstinence Syndrome (NAS) Neonatal Opioid Withdrawal Syndrome (NOWS)

Journal

Seminars in fetal & neonatal medicine
ISSN: 1878-0946
Titre abrégé: Semin Fetal Neonatal Med
Pays: Netherlands
ID NLM: 101240003

Informations de publication

Date de publication:
Apr 2019
Historique:
pubmed: 3 2 2019
medline: 27 11 2019
entrez: 3 2 2019
Statut: ppublish

Résumé

Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure is a growing epidemic with significant variability in clinical presentation and severity. Currently, NAS severity cannot be predicted based on clinical factors alone. To date, small studies have identified genetic variants in opioid receptor and stress response genes that are associated with differences in NAS pharmacologic treatment rates and length of hospitalization. In addition, epigenetic variation in the mu opioid receptor (OPRM1) gene has been associated with differences in NAS hospitalization outcomes. Examination of maternal genetic and epigenetic profiles may assist in prediction of NAS severity. Large-scale genomic studies are needed to elucidate the genetic architecture of and epigenetic modification related to NAS in order to develop more tailored personalized treatments for NAS.

Identifiants

DOI: 10.1016/j.siny.2019.01.002 PMID: 30709700
pubmed: 30709700
pii: S1744-165X(19)30010-1
doi: 10.1016/j.siny.2019.01.002
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Receptors, Opioid, mu 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105-110

Informations de copyright

© 2019 Elsevier Ltd. All rights reserved.

Auteurs

Elisha M Wachman (EM)

Department of Pediatrics, Boston Medical Center, Boston, MA, USA; Grayken Center for Addiction Medicine, Boston Medical Center, Boston, MA, USA. Electronic address: Elisha.Wachman@bmc.org.

Lindsay A Farrer (LA)

Departments of Medicine (Biomedical Genetics), Neurology, Ophthalmology, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA. Electronic address: farrer@bu.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › The genetics and epigenetics of Neonatal...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The genetics and epigenetics of Neonatal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The genetics and epigenetics of Neonatal...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › The genetics and epigenetics of Neonatal...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Syndrome de sevrage néonatal › The genetics and epigenetics of Neonatal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › The genetics and epigenetics of Neonatal...