Designing Calcium-Binding Proteins for Molecular MR Imaging.
Animals
Calcium
/ metabolism
Cell Line, Tumor
Contrast Media
/ chemical synthesis
Early Detection of Cancer
Gadolinium
/ chemistry
Humans
Kallikreins
/ metabolism
Magnetic Resonance Imaging
/ methods
Male
Mice
Models, Molecular
Molecular Conformation
Molecular Imaging
/ methods
Neoplasm Transplantation
Parvalbumins
/ chemistry
Prostate-Specific Antigen
/ metabolism
Prostatic Neoplasms
/ diagnostic imaging
Protein Engineering
/ methods
CaBP
Contrast agent
MRI
Molecular imaging
PSMA
Parvalbumin
ProCA
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
3
2
2019
pubmed:
3
2
2019
medline:
25
6
2019
Statut:
ppublish
Résumé
Early diagnosis, noninvasive detection, and staging of various diseases, remain one of the major clinical barriers to effective medical treatment and prevention of disease progression toward major clinical consequences. Molecular imaging technologies play an indispensable role in the clinical field in overcoming these major barriers. The increasing application of imaging techniques and agents in early detection of different diseases such as cancer has resulted in improved treatment response and clinical patient management. In this chapter we will first introduce criteria for the design and engineering of calcium-binding protein (CaBP) parvalbumin as a protein Gd-MRI contrast agent (ProCA) with unprecedented metal selectivity for Gd
Identifiants
pubmed: 30710270
doi: 10.1007/978-1-4939-9030-6_8
pmc: PMC6542288
mid: NIHMS1024624
doi:
Substances chimiques
Contrast Media
0
Parvalbumins
0
Gadolinium
AU0V1LM3JT
KLK3 protein, human
EC 3.4.21.-
Kallikreins
EC 3.4.21.-
Prostate-Specific Antigen
EC 3.4.21.77
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-125Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB007268
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM081749
Pays : United States
Organisme : NIAAA NIH HHS
ID : R42 AA025863
Pays : United States
Organisme : NCI NIH HHS
ID : R42 CA183376
Pays : United States
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