Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma.
Adult
Aged
Aged, 80 and over
Carcinoma, Basal Cell
/ pathology
Facial Neoplasms
/ pathology
Female
Head and Neck Neoplasms
/ pathology
Humans
Male
Margins of Excision
Middle Aged
Mohs Surgery
Neoplasm Invasiveness
Organ Sparing Treatments
/ methods
Prospective Studies
Scalp
Skin Neoplasms
/ pathology
Treatment Outcome
Tumor Burden
Mohs micrographic surgery
basal cell carcinoma
tissue sparing
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
21
10
2018
revised:
20
12
2018
accepted:
25
01
2019
pubmed:
3
2
2019
medline:
29
10
2019
entrez:
3
2
2019
Statut:
ppublish
Résumé
Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared with standard surgical excision because smaller surgical margins are used. To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern. A prospective study including 256 primary BCCs with an infiltrative growth pattern was performed. Tumor sizes were measured in 2 perpendicular directions. Surface defect areas after MMS were measured. The suspected defect surface area with standard excision using a 5-mm margin was calculated. The primary outcome of this study was the size of the defect surface area spared with MMS compared with the calculated defect surface area with a standard excision. The median tumor size was 71 mm Single-center study design. Lack of a randomized control group for ethical reasons. A rate of tissue sparing of 46% can be reached by using MMS for primary BCC with an infiltrative growth pattern.
Sections du résumé
BACKGROUND
BACKGROUND
Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared with standard surgical excision because smaller surgical margins are used.
OBJECTIVE
OBJECTIVE
To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern.
METHODS
METHODS
A prospective study including 256 primary BCCs with an infiltrative growth pattern was performed. Tumor sizes were measured in 2 perpendicular directions. Surface defect areas after MMS were measured. The suspected defect surface area with standard excision using a 5-mm margin was calculated. The primary outcome of this study was the size of the defect surface area spared with MMS compared with the calculated defect surface area with a standard excision.
RESULTS
RESULTS
The median tumor size was 71 mm
LIMITATIONS
CONCLUSIONS
Single-center study design. Lack of a randomized control group for ethical reasons.
CONCLUSION
CONCLUSIONS
A rate of tissue sparing of 46% can be reached by using MMS for primary BCC with an infiltrative growth pattern.
Identifiants
pubmed: 30710602
pii: S0190-9622(19)30166-5
doi: 10.1016/j.jaad.2019.01.057
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1700-1703Informations de copyright
Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.