Magnetically-guided hydrogel capsule motors produced via ultrasound assisted hydrodynamic electrospray ionization jetting.

Alginates / chemistry Capsules / chemistry Electrochemistry Hydrodynamics Hydrogels / chemistry Magnetic Fields Ultrasonic Waves
Biodegradable Electrospraying Hydrogel capsules Magnetic guidance Motors

Journal

Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125

Informations de publication

Date de publication:
01 Apr 2019
Historique:
received: 25 10 2018
revised: 22 01 2019
accepted: 23 01 2019
pubmed: 3 2 2019
medline: 14 6 2019
entrez: 3 2 2019
Statut: ppublish

Résumé

Hydrogel capsules are a potential candidate for drug delivery and an interesting alternative to polyelectrolyte multilayer capsules which are under investigation since 20 years. Recently introduced polyelectrolyte complex capsules produced by spraying are non-biodegradable and not biocompatible, which limits their practical application, while biodegradable alginate capsules require complex coaxial electrospray ionization jetting. In this work, biodegradable alginate capsules cross-linked by calcium are successfully produced by hydrodynamic electrospray ionization jetting with the assistance of low frequency ultrasound. The size and shape of most capsules show significant differences with respect to different spraying distance, spraying mode, electrode shape and spraying concentration. Capsules in the shape of vase, mushrooms and spheres were successfully produced. Average capsule size can be adjusted from 10 μm to 2 mm. These capsules are used to encapsulate a model drug. Encapsulated paramagnetic particles enable defined directional motion under the propulsion of a rotating magnetic field, while model drugs can be released by ultrasound.

Identifiants

DOI: 10.1016/j.jcis.2019.01.103 PMID: 30710823
pubmed: 30710823
pii: S0021-9797(19)30125-0
doi: 10.1016/j.jcis.2019.01.103
pii:
doi:

Substances chimiques

Alginates 0
Capsules 0
Hydrogels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

407-417

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Sven Rutkowski (S)

Key Lab of Microsystems and Microstructures Manufacturing, Yikuang Street 2 B1, Harbin Institute of Technology, Harbin 150080, PR China.

Tieyan Si (T)

Physics Department, Yikuang Street 2 2H, School of Science, Harbin Institute of Technology, Harbin 150080, PR China. Electronic address: Tieyansi@hit.edu.cn.

Meiyu Gai (M)

Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany; National Research Tomsk Polytechnic University, 634050 Tomsk, Russian Federation.

Mengmeng Sun (M)

Key Lab of Microsystems and Microstructures Manufacturing, Yikuang Street 2 B1, Harbin Institute of Technology, Harbin 150080, PR China.

Johannes Frueh (J)

Key Lab of Microsystems and Microstructures Manufacturing, Yikuang Street 2 B1, Harbin Institute of Technology, Harbin 150080, PR China; National Research Tomsk Polytechnic University, 634050 Tomsk, Russian Federation; Institute of Environmental Engineering, ETH Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland. Electronic address: Johannes.frueh@hit.edu.cn.

Qiang He (Q)

Key Lab of Microsystems and Microstructures Manufacturing, Yikuang Street 2 B1, Harbin Institute of Technology, Harbin 150080, PR China. Electronic address: Qianghe@hit.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Alginates › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Préparations pharmaceutiques › Capsules › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie physique › Électrochimie › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Phénomènes physiques › Hydrodynamique › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Champs magnétiques › Magnetically-guided hydrogel capsule motors...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Son (physique) › Ondes ultrasonores › Magnetically-guided hydrogel capsule motors...