Higher Risk of Fragility Fractures in Prostate Cancer Patients Treated with Combined Radium-223 and Abiraterone: Prednisone May Be the Culprit.

Abiraterone Acetate Androstenes Antineoplastic Combined Chemotherapy Protocols Fractures, Bone Humans Male Prednisone Prostatic Neoplasms, Castration-Resistant Radium Treatment Outcome

Journal

European urology
ISSN: 1873-7560
Titre abrégé: Eur Urol
Pays: Switzerland
ID NLM: 7512719

Informations de publication

Date de publication:
06 2019
Historique:
received: 25 12 2018
accepted: 17 01 2019
pubmed: 4 2 2019
medline: 7 10 2020
entrez: 4 2 2019
Statut: ppublish

Résumé

Results from the ERA 223 trial of abiraterone combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events. We hypothesize that this finding might be attributable to bone loss induced by the concomitantly administered prednisone.

Identifiants

DOI: 10.1016/j.eururo.2019.01.026 PMID: 30711330
pubmed: 30711330
pii: S0302-2838(19)30069-7
doi: 10.1016/j.eururo.2019.01.026
pii:
doi:

Substances chimiques

Androstenes 0
Radium-223 8BR2SOL3L1
Abiraterone Acetate EM5OCB9YJ6
abiraterone G819A456D0
Prednisone VB0R961HZT
Radium W90AYD6R3Q

Types de publication

Editorial Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

894-895

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Auteurs

Alberto Dalla Volta (A)

Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy.

Anna Maria Formenti (AM)

Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy.

Alfredo Berruti (A)

Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy. Electronic address: alfredo.berruti@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Androstanes › Androstènes › Acétate d'abiratérone › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Androstanes › Androstènes › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnadiènes › Prégnadiènediols › Prednisone › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Tumeurs prostatiques résistantes à la castration › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Radium › Higher Risk of Fragility Fractures in Prostate...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Higher Risk of Fragility Fractures in Prostate...