Uterus transplantation and fertility preservation.
Infertility
Transplantation
Uterus
Journal
Best practice & research. Clinical obstetrics & gynaecology
ISSN: 1532-1932
Titre abrégé: Best Pract Res Clin Obstet Gynaecol
Pays: Netherlands
ID NLM: 101121582
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
14
12
2018
accepted:
14
12
2018
pubmed:
4
2
2019
medline:
6
6
2019
entrez:
4
2
2019
Statut:
ppublish
Résumé
Absolute uterine factor infertility (AUFI), with uterine absence or presence of a non-functional uterus, was considered untreatable until 2014, when the first child was born after transplantation of a uterus from a postmenopausal woman to a woman of fertile age who was born with no uterus, as a part of the Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Concerning gynaecological cancer, AUFI may occur after hysterectomy for malignancy or after surgery/radiation that will preserve the uterus but causing non-functionality in terms of future implantation and pregnancy. This review summarises the research preparations that paved the way for the clinical introduction of uterus transplantation (UTx) as a treatment for AUFI. We also summarise the human UTx attempts that have been published as well as the live births reported thus far. The clinical use and procedures for UTx are also proposed for a number of gynaecological malignancies.
Identifiants
pubmed: 30711374
pii: S1521-6934(18)30275-X
doi: 10.1016/j.bpobgyn.2018.12.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-116Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.