Exceptional human longevity is associated with a specific plasma phenotype of ether lipids.
Alkenyl phospholipids
Alkyl phospholipids
Centenarians
Fatty acid unsaturation
Mass spectrometry
Phosphatidylcholine
Phosphatidylethanolamine
Plasmalogens
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
11
2018
revised:
09
01
2019
accepted:
28
01
2019
pubmed:
4
2
2019
medline:
2
4
2019
entrez:
4
2
2019
Statut:
ppublish
Résumé
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging.
Identifiants
pubmed: 30711699
pii: S2213-2317(18)31058-9
doi: 10.1016/j.redox.2019.101127
pmc: PMC6357979
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101127Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Cell Rep. 2018 Sep 4;24(10):2757-2772
pubmed: 30184508
Aging Cell. 2012 Oct;11(5):845-55
pubmed: 22708840
Age (Dordr). 2011 Jun;33(2):219-27
pubmed: 20811950
Nat Rev Endocrinol. 2017 Feb;13(2):79-91
pubmed: 27767036
Chem Phys Lipids. 2011 Sep;164(6):573-89
pubmed: 21723266
J Alzheimers Dis. 2017;59(2):433-444
pubmed: 28582856
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):30-37
pubmed: 27013396
Sci Rep. 2017 Dec;7(1):5
pubmed: 28127055
Biochim Biophys Acta. 2008 Oct;1777(10):1249-62
pubmed: 18721793
J Nutr Sci Vitaminol (Tokyo). 2008 Jun;54(3):196-202
pubmed: 18635905
Mol Biol Evol. 2010 Apr;27(4):840-7
pubmed: 19955481
Exp Gerontol. 2007 Nov;42(11):1053-62
pubmed: 18029129
Mech Ageing Dev. 2015 Sep;150:27-33
pubmed: 26254886
J Lipid Res. 2016 Feb;57(2):265-75
pubmed: 26685325
Biochim Biophys Acta. 2012 Sep;1822(9):1442-52
pubmed: 22627108
Protein Cell. 2018 Feb;9(2):196-206
pubmed: 28523433
Physiol Rev. 2007 Oct;87(4):1175-213
pubmed: 17928583
J Atheroscler Thromb. 2007 Feb;14(1):12-8
pubmed: 17332687
Chem Rev. 2011 Oct 12;111(10):5944-72
pubmed: 21861450
J Am Geriatr Soc. 2001 Jan;49(1):76-9
pubmed: 11207846
Front Physiol. 2017 Oct 24;8:812
pubmed: 29123486
Prog Lipid Res. 2010 Oct;49(4):493-8
pubmed: 20637230
Gerontology. 1998;44(2):106-10
pubmed: 9523222
Sci Rep. 2013 Nov 28;3:3346
pubmed: 24284984
Aging (Albany NY). 2016 Oct 28;8(12):3185-3208
pubmed: 27794564
Science. 2002 May 10;296(5570):1029-31
pubmed: 12004104
Aging Cell. 2013 Jun;12(3):426-34
pubmed: 23451766
Curr Opin Cardiol. 2011 Jul;26(4):348-55
pubmed: 21478743
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2723-32
pubmed: 21903946
Front Physiol. 2013 Dec 17;4:372
pubmed: 24381560
Mech Ageing Dev. 2017 Jul;165(Pt B):55-58
pubmed: 28651996
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1269-75
pubmed: 24509978
Biogerontology. 2013 Dec;14(6):663-72
pubmed: 23948799
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8442-7
pubmed: 12060785