Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish.
Biological Sciences
Developmental Biology
Embryology
Mathematical Biosciences
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Feb 2019
22 Feb 2019
Historique:
received:
10
08
2018
revised:
31
12
2018
accepted:
16
01
2019
pubmed:
4
2
2019
medline:
4
2
2019
entrez:
4
2
2019
Statut:
ppublish
Résumé
Gene regulatory networks govern pattern formation and differentiation during embryonic development. Segmentation of somites, precursors of the vertebral column among other tissues, is jointly controlled by temporal signals from the segmentation clock and spatial signals from morphogen gradients. To explore how these temporal and spatial signals are integrated, we combined time-controlled genetic perturbation experiments with computational modeling to reconstruct the core segmentation network in zebrafish. We found that Mesp family transcription factors link the temporal information of the segmentation clock with the spatial action of the fibroblast growth factor signaling gradient to establish rostrocaudal (head to tail) polarity of segmented somites. We further showed that cells gradually commit to patterning by the action of different genes at different spatiotemporal positions. Our study provides a blueprint of the zebrafish segmentation network, which includes evolutionarily conserved genes that are associated with the birth defect congenital scoliosis in humans.
Identifiants
pubmed: 30711748
pii: S2589-0042(19)30022-7
doi: 10.1016/j.isci.2019.01.021
pmc: PMC6360518
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
247-259Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM111987
Pays : United States
Organisme : NIAMS NIH HHS
ID : R15 AR066284
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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