Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA.
Apoptosis
Coxsackievirus
MicroRNA
Vesicles
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
09
10
2018
revised:
28
01
2019
accepted:
29
01
2019
pubmed:
4
2
2019
medline:
16
7
2019
entrez:
4
2
2019
Statut:
ppublish
Résumé
Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus. Though microRNAs are differentially regulated in cells following infection, few have been associated with the vesicles shed from infected cells. Here we report exclusive trafficking of specific microRNAs into viral vesicles compared to vesicles from non-infected cells. We found that the most highly-expressed unique microRNA in viral vesicles was miR-590-5p, which facilitates prolonged viral replication by blocking apoptotic factors. Cells over-expressing this miR were significantly more susceptible to infection. This may be a mechanism by which coxsackievirus B boosts subsequent rounds of infection by co-packaging virus and a select set of pro-viral microRNAs in extracellular vesicles.
Identifiants
pubmed: 30711774
pii: S0042-6822(19)30029-7
doi: 10.1016/j.virol.2019.01.025
pmc: PMC6382511
mid: NIHMS1519979
pii:
doi:
Substances chimiques
MIRN590 microRNA, human
0
MicroRNAs
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-176Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001882
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL112730
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL116273
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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