Tumorous CD10 Is More Strongly Related to the Progression of Urothelial Carcinoma than Stromal CD10.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ metabolism
Carcinogenesis
Carcinoma
/ metabolism
Disease Progression
Female
Gene Expression Profiling
Humans
Immunohistochemistry
Male
Middle Aged
Multivariate Analysis
Neprilysin
/ metabolism
Oligonucleotide Array Sequence Analysis
Prognosis
Stromal Cells
/ metabolism
Treatment Outcome
Urinary Bladder Neoplasms
/ metabolism
Urothelium
/ metabolism
CD10
progression
survival
tumor stroma
urothelial carcinoma
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
07
12
2018
revised:
13
12
2018
accepted:
14
12
2018
entrez:
4
2
2019
pubmed:
4
2
2019
medline:
21
3
2019
Statut:
ppublish
Résumé
CD10 function in urothelial carcinoma (UC) remains controversial. We previously reported that miR-21 in UC may be a prognostic marker for cancer progression. The aim of this study was to examine the clinicopathological significance of CD10 expression in UC and its relationship with miR-21 expression. Immunohistochemistry for CD10 was performed on 232 UCs. CD10 expression in TCs and stroma was evaluated respectively, and its association with carcinogenesis and survival was analyzed. High tumorous CD10 was significantly associated with higher tumor stage, histological grade and vessel infiltration, and poorer prognosis, whereas stromal CD10 was significantly associated with younger age, higher tumor stage, and vessel infiltration. On multivariable analysis, CD10 expression in TCs, miR-21 expression in TCs and TS, and tumor stage were independent prognostic factors. Tumorous CD10 is more strongly related to progression of UC than stromal CD10 and is an independent factor for UC prognosis.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
CD10 function in urothelial carcinoma (UC) remains controversial. We previously reported that miR-21 in UC may be a prognostic marker for cancer progression. The aim of this study was to examine the clinicopathological significance of CD10 expression in UC and its relationship with miR-21 expression.
MATERIALS AND METHODS
METHODS
Immunohistochemistry for CD10 was performed on 232 UCs. CD10 expression in TCs and stroma was evaluated respectively, and its association with carcinogenesis and survival was analyzed.
RESULTS
RESULTS
High tumorous CD10 was significantly associated with higher tumor stage, histological grade and vessel infiltration, and poorer prognosis, whereas stromal CD10 was significantly associated with younger age, higher tumor stage, and vessel infiltration. On multivariable analysis, CD10 expression in TCs, miR-21 expression in TCs and TS, and tumor stage were independent prognostic factors.
CONCLUSION
CONCLUSIONS
Tumorous CD10 is more strongly related to progression of UC than stromal CD10 and is an independent factor for UC prognosis.
Identifiants
pubmed: 30711939
pii: 39/2/635
doi: 10.21873/anticanres.13157
doi:
Substances chimiques
Biomarkers, Tumor
0
Neprilysin
EC 3.4.24.11
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
635-640Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.