Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection.
Human papillomavirus
p16 protein
tongue cancer
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
5
2
2019
medline:
25
6
2019
entrez:
5
2
2019
Statut:
ppublish
Résumé
Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors. The present study investigated the relationship between TC and human papillomavirus (HPV) infection. Clinical records and surgically resected specimens from 86 patients (<40-years-old, n = 12; ≥40-years-old, n = 74) with TC were analyzed. Strong nuclear and cytoplasmic p16 staining was considered positive. HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11) was detected using consensus primer-mediated polymerase chain reaction. Strong p16 expression was observed in 10 (11.6%) patients. HPV DNA was detected in 9 (10.5%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 7). Strong p16 expression was observed more frequently among younger adults than among older adults (33.3% vs. 8.1%; p = .045). p16 staining did not correlate with the detection of HPV DNA (correlation coefficient, 0.113; p = .300). In TC, p16 expression was not associated with HPV infection, suggesting that it may be caused by a different mechanism.
Sections du résumé
BACKGROUND
BACKGROUND
Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors.
OBJECTIVES
OBJECTIVE
The present study investigated the relationship between TC and human papillomavirus (HPV) infection.
MATERIAL AND METHODS
METHODS
Clinical records and surgically resected specimens from 86 patients (<40-years-old, n = 12; ≥40-years-old, n = 74) with TC were analyzed. Strong nuclear and cytoplasmic p16 staining was considered positive. HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11) was detected using consensus primer-mediated polymerase chain reaction.
RESULTS
RESULTS
Strong p16 expression was observed in 10 (11.6%) patients. HPV DNA was detected in 9 (10.5%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 7). Strong p16 expression was observed more frequently among younger adults than among older adults (33.3% vs. 8.1%; p = .045). p16 staining did not correlate with the detection of HPV DNA (correlation coefficient, 0.113; p = .300).
CONCLUSIONS AND SIGNIFICANCE
CONCLUSIONS
In TC, p16 expression was not associated with HPV infection, suggesting that it may be caused by a different mechanism.
Identifiants
pubmed: 30712427
doi: 10.1080/00016489.2018.1541506
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM