Human African Trypanosomiasis: Progress and Stagnation.

Africa Animals Antiprotozoal Agents / therapeutic use Cost of Illness Drug Therapy, Combination Humans Prevalence Travel Trypanosomiasis, African / diagnosis
Clinical presentation Diagnosis Human African trypanosomiasis Treatment Trypanosoma brucei gambiense Trypanosoma brucei rhodesiense

Journal

Infectious disease clinics of North America
ISSN: 1557-9824
Titre abrégé: Infect Dis Clin North Am
Pays: United States
ID NLM: 8804508

Informations de publication

Date de publication:
03 2019
Historique:
entrez: 5 2 2019
pubmed: 5 2 2019
medline: 8 11 2019
Statut: ppublish

Résumé

Control efforts have considerably reduced the prevalence of human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in West/Central Africa and to Trypanosoma brucei rhodesiense in East Africa. Management of T brucei gambiense HAT has recently improved, with new antibody-based rapid diagnostic tests suited for mass screening and clinical care, and simpler treatments, including the nifurtimox-eflornithine combination therapy and the new oral drug fexinidazole to treat the second stage of the disease. In contrast, no major advance has been achieved for the treatment of T brucei rhodesiense HAT, a zoonosis that occasionally affects short-term travelers to endemic areas.

Identifiants

DOI: 10.1016/j.idc.2018.10.003 PMID: 30712768
pubmed: 30712768
pii: S0891-5520(18)30090-4
doi: 10.1016/j.idc.2018.10.003
pii:
doi:

Substances chimiques

Antiprotozoal Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

61-77

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Emmanuel Bottieau (E)

Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 155, Antwerpen 2000, Belgium. Electronic address: ebottieau@itg.be.

Jan Clerinx (J)

Department of Clinical Sciences, Institute of Tropical Medicine, Nationalestraat 155, Antwerpen 2000, Belgium.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Afrique › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Eucaryotes › Animaux › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Coûts indirects de la maladie › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Activités humaines › Voyage › Human African Trypanosomiasis: Progress and Stagnation.
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie du sommeil › Human African Trypanosomiasis: Progress and Stagnation.