The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT): Study Design and Participants.
JPHC-NEXT
genomic research
population-based cohort
Journal
Journal of epidemiology
ISSN: 1349-9092
Titre abrégé: J Epidemiol
Pays: Japan
ID NLM: 9607688
Informations de publication
Date de publication:
05 Jan 2020
05 Jan 2020
Historique:
pubmed:
5
2
2019
medline:
1
7
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Lifestyle and life-environment factors have undergone drastic changes in Japan over the last few decades. Further, many molecular epidemiologic studies have reported that genetic, epigenetic, and other biomarker information may be useful in predicting individual disease risk. The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) was launched in 2011 to identify risk factors for lifestyle-related disease, elucidate factors that extend healthy life expectancy, and contribute toward personalized healthcare based on our more than 20 years' experience with the JPHC Study. From 2011 through 2016, a baseline survey was conducted at 16 municipalities in seven prefectures across the country. A self-administered questionnaire was distributed to all registered residents aged 40-74, which mainly asked about lifestyle factors, such as socio-demographic situation, personal medical history, smoking, alcohol and dietary habits. We obtained informed consent from each participant to participate in this long follow-up study of at least 20 years, including consent to the potential use of their residence registry, medical records, medical fee receipts, care insurance etc., and to the provision of biospecimens (blood and urine), including genomic analysis. As of December 31, 2016, we have established a population-based cohort of 115,385 persons (Response rate 44.1%), among whom 55,278 (47.9% of participants) have provided blood and urine samples. The participation rate was slightly higher among females and in the older age group. We have established a large-scale population-based cohort for next-generation epidemiological study in Japan.
Sections du résumé
BACKGROUND
BACKGROUND
Lifestyle and life-environment factors have undergone drastic changes in Japan over the last few decades. Further, many molecular epidemiologic studies have reported that genetic, epigenetic, and other biomarker information may be useful in predicting individual disease risk.
METHODS
METHODS
The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) was launched in 2011 to identify risk factors for lifestyle-related disease, elucidate factors that extend healthy life expectancy, and contribute toward personalized healthcare based on our more than 20 years' experience with the JPHC Study. From 2011 through 2016, a baseline survey was conducted at 16 municipalities in seven prefectures across the country. A self-administered questionnaire was distributed to all registered residents aged 40-74, which mainly asked about lifestyle factors, such as socio-demographic situation, personal medical history, smoking, alcohol and dietary habits. We obtained informed consent from each participant to participate in this long follow-up study of at least 20 years, including consent to the potential use of their residence registry, medical records, medical fee receipts, care insurance etc., and to the provision of biospecimens (blood and urine), including genomic analysis.
RESULTS
RESULTS
As of December 31, 2016, we have established a population-based cohort of 115,385 persons (Response rate 44.1%), among whom 55,278 (47.9% of participants) have provided blood and urine samples. The participation rate was slightly higher among females and in the older age group.
CONCLUSION
CONCLUSIONS
We have established a large-scale population-based cohort for next-generation epidemiological study in Japan.
Identifiants
pubmed: 30713262
doi: 10.2188/jea.JE20180182
pmc: PMC6908844
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-54Références
J Epidemiol. 2001 Oct;11(6 Suppl):S24-9
pubmed: 11763136
J Epidemiol. 2016 Sep 5;26(9):493-511
pubmed: 27374138
J Clin Epidemiol. 2002 Feb;55(2):150-6
pubmed: 11809353
Int J Cancer. 2016 Jan 15;138(2):320-31
pubmed: 26219435
Cancer Prev Res (Phila). 2017 Sep;10(9):535-541
pubmed: 28729251
Stroke. 2017 Feb;48(2):253-258
pubmed: 28034966
Prev Med. 2009 Feb;48(2):128-33
pubmed: 19071158
Jpn J Clin Oncol. 2014 Sep;44(9):777-82
pubmed: 25104790
Genet Epidemiol. 2016 Jul;40(5):356-65
pubmed: 27061572
J Epidemiol. 2003 Jul;13(4):216-25
pubmed: 12934965
J Epidemiol. 2016 Aug 5;26(8):420-32
pubmed: 27064130
World J Gastroenterol. 2014 Jul 28;20(28):9600-10
pubmed: 25071358
Geriatr Gerontol Int. 2018 May;18(5):738-744
pubmed: 29336097
Asian Pac J Cancer Prev. 2007 Apr-Jun;8(2):317-23
pubmed: 17696755
Br J Cancer. 2016 Jan 19;114(2):125-33
pubmed: 26757262