Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase.
Acyl Carrier Protein
Anti-Bacterial Agents
/ chemistry
Bacterial Proteins
/ antagonists & inhibitors
Enzyme Inhibitors
/ chemistry
Oxidoreductases
/ antagonists & inhibitors
Pseudomonas aeruginosa
/ drug effects
Rhodanine
/ analogs & derivatives
Staphylococcus aureus
/ drug effects
Structure-Activity Relationship
DNA Gyrase B
bacterial infection
computer assistant drug design
enoyl-acyl carrier protein reductase
molecular docking
rhodanine
Journal
Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
5
2
2019
pubmed:
5
2
2019
medline:
29
9
2019
Statut:
ppublish
Résumé
Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC
Identifiants
pubmed: 30713272
doi: 10.1248/cpb.c18-00663
doi:
Substances chimiques
Acyl Carrier Protein
0
Anti-Bacterial Agents
0
Bacterial Proteins
0
Enzyme Inhibitors
0
Rhodanine
7O50LKL2G8
Oxidoreductases
EC 1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM