Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
B16 melanoma
CD28
IFN-γ
PD-1
Tumor-infiltrating T cells
mRNA stability
post-transcriptional regulation
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
Historique:
received:
20
06
2018
revised:
20
09
2018
accepted:
26
09
2018
entrez:
5
2
2019
pubmed:
5
2
2019
medline:
5
2
2019
Statut:
epublish
Résumé
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells. Dissecting the underlying mechanisms that block cytokine production is thus key for improving T cell products. Here we show that although TILs express substantial levels of
Identifiants
pubmed: 30713785
doi: 10.1080/2162402X.2018.1532762
pii: 1532762
pmc: PMC6343783
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e1532762Références
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