Interaction between IGF2-PI3K axis and cancer-associated-fibroblasts promotes anal squamous carcinogenesis.
Animals
Anus Neoplasms
/ genetics
Cancer-Associated Fibroblasts
/ metabolism
Carcinoma, Squamous Cell
/ genetics
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
Insulin-Like Growth Factor II
/ genetics
Male
Mice
Mutation
Neoplasm Transplantation
Paracrine Communication
Phosphatidylinositol 3-Kinases
/ metabolism
Signal Transduction
IGF2
PDGFRB
PI3K
anal cancer
cancer-associated fibroblast
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
01
06
2018
revised:
03
12
2018
accepted:
28
01
2019
pubmed:
5
2
2019
medline:
18
1
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Anal squamous cell carcinoma (ASCC) is a rare tumour, but its incidence is increasing. Standard chemoradiotherapy fails to cure 20% of patients and no targeted therapy is currently approved for recurrent ASCC. The PI3K/Akt/mTOR pathway is frequently altered in this poorly characterised carcinoma
Substances chimiques
IGF2 protein, human
0
Insulin-Like Growth Factor II
67763-97-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1852-1859Informations de copyright
© 2019 UICC.