Antimicrobial and Cytotoxic Activities of Lepidium latifolium L. Hydrodistillate, Extract and Its Major Sulfur Volatile Allyl Isothiocyanate.
Antifungal Agents
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Candida albicans
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Isothiocyanates
/ chemistry
Lepidium
/ chemistry
Microbial Sensitivity Tests
Molecular Structure
Plant Extracts
/ chemistry
Structure-Activity Relationship
Lepidium latifolium L.
allyl isothiocyanate
antimicrobial activity
cytotoxicity
glucosinolates
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
11
12
2018
accepted:
31
01
2019
pubmed:
5
2
2019
medline:
29
5
2019
entrez:
5
2
2019
Statut:
ppublish
Résumé
The cultivated Lepidium latifolium L. was investigated to decipher its glucosinolate profile, antimicrobial, and cytotoxic activities. HPLC/ESI-MS analyses of the intact glucosinolates and GC/MS analysis of their hydrolysis products showed the presence of sinigrin (1), glucocochlearin (2), glucotropaeolin (3), and 4-methoxyglucobrassicin (4). Hydrodistillate, extract, and allyl isothiocyanate, the main volatile resulting from sinigrin degradation, showed antimicrobial activity against all eleven tested pathogenic and food spoilage bacteria and fungi, with highest effect observed against Candida albicans with MIC
Identifiants
pubmed: 30714673
doi: 10.1002/cbdv.201800661
doi:
Substances chimiques
Antifungal Agents
0
Antineoplastic Agents, Phytogenic
0
Isothiocyanates
0
Plant Extracts
0
allyl isothiocyanate
BN34FX42G3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1800661Subventions
Organisme : Croatian Science Foundation
ID : IP-2016-06-1316
Organisme : Natural Sciences and Engieering Research Council of Canada
ID : 315095-05
Organisme : Canadian Foundation for Innovation
ID : 11666
Informations de copyright
© 2019 Wiley-VHCA AG, Zurich, Switzerland.