CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.
CCL2
ROCV
encephalitis
macrophages
pathogenesis
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
24 05 2019
24 05 2019
Historique:
received:
10
01
2019
accepted:
24
01
2019
pubmed:
5
2
2019
medline:
25
2
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Rocio virus (ROCV) is a highly neuropathogenic mosquito-transmitted flavivirus responsible for an unprecedented outbreak of human encephalitis during 1975-1976 in Sao Paulo State, Brazil. Previous studies have shown an increased number of inflammatory macrophages in the central nervous system (CNS) of ROCV-infected mice, implying a role for macrophages in the pathogenesis of ROCV. Here, we show that ROCV infection results in increased expression of CCL2 in the blood and in infiltration of macrophages into the brain. Moreover, we show, using CCR2 knockout mice, that CCR2 expression is essential for macrophage infiltration in the brain during ROCV infection and that the lack of CCR2 results in increased disease severity and mortality. Thus, our findings show the protective role of CCR2-mediated infiltration of macrophages in the brain during ROCV infection.
Identifiants
pubmed: 30715407
pii: 5306303
doi: 10.1093/infdis/jiz029
pmc: PMC7107438
doi:
Substances chimiques
Ccr2 protein, mouse
0
Receptors, CCR2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2015-2025Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Références
Sci Rep. 2014 Jun 18;4:5344
pubmed: 24938868
Arch Virol. 2018 Jan;163(1):255-258
pubmed: 28939977
J Immunol. 2016 Jun 1;196(11):4622-31
pubmed: 27183602
PLoS One. 2018 Jun 13;13(6):e0199071
pubmed: 29897990
J Neurol Sci. 1980 Feb;45(1):1-12
pubmed: 7359160
PLoS Pathog. 2012;8(11):e1003039
pubmed: 23209411
Clin Infect Dis. 2000 Oct;31(4):1116-7
pubmed: 11049802
PLoS One. 2016 Dec 8;11(12):e0168034
pubmed: 27930721
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8929-E8938
pubmed: 30181265
Am J Trop Med Hyg. 1978 Mar;27(2 Pt 2 Suppl):372-440
pubmed: 646031
J Venom Anim Toxins Incl Trop Dis. 2014 Mar 25;20(1):9
pubmed: 24666635
J Infect Dis. 2010 Dec 15;202(12):1804-12
pubmed: 21050124
Nat Rev Immunol. 2011 Oct 10;11(11):762-74
pubmed: 21984070
PLoS One. 2013 Aug 05;8(8):e71643
pubmed: 23940775
J Immunol. 2011 Jan 1;186(1):471-8
pubmed: 21131425
Annu Rev Immunol. 2008;26:421-52
pubmed: 18303997
Curr Protoc Immunol. 2010 Feb;Chapter 15:Unit 15.1
pubmed: 20143314
PLoS One. 2012;7(8):e44153
pubmed: 22952908
Brain. 2009 Sep;132(Pt 9):2487-500
pubmed: 19531531
Brain Pathol. 2008 Jan;18(1):40-51
pubmed: 17935605
Trends Pharmacol Sci. 2008 Dec;29(12):626-32
pubmed: 18835047
Am J Trop Med Hyg. 2011 Aug;85(2):363-73
pubmed: 21813860
PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2706
pubmed: 24551266
Rev Soc Bras Med Trop. 2014 Jul;47(4):414-7
pubmed: 25229279
BMC Microbiol. 2015 Sep 29;15:189
pubmed: 26415508
Rev Inst Med Trop Sao Paulo. 1994 May-Jun;36(3):265-74
pubmed: 7855491
Am J Epidemiol. 1978 Nov;108(5):394-401
pubmed: 727209
J Immunol. 2008 Nov 1;181(9):6417-26
pubmed: 18941232
Virology. 2004 Nov 24;329(2):251-60
pubmed: 15518805
Glia. 2007 Apr 1;55(5):483-96
pubmed: 17203475
J Gen Virol. 2007 Aug;88(Pt 8):2237-46
pubmed: 17622628
J Neurosci Res. 2005 Aug 1;81(3):374-89
pubmed: 15959904
Am J Med. 2004 Nov 1;117(9):710-1
pubmed: 15501215
Clin Exp Immunol. 1979 Dec;38(3):492-8
pubmed: 231492
J Vis Exp. 2016 Feb 12;(108):53658
pubmed: 26967380
Am J Epidemiol. 1978 May;107(5):444-9
pubmed: 665659
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7438-42
pubmed: 1651506
Rev Soc Bras Med Trop. 1997 Nov-Dec;30(6):511-5
pubmed: 9463199
J Immunol. 2015 Nov 1;195(9):4306-18
pubmed: 26401006
J Neuroinflammation. 2016 Jun 22;13(1):159
pubmed: 27334012
J Exp Med. 2008 Sep 29;205(10):2319-37
pubmed: 18779347
AMB Rev Assoc Med Bras. 1976 Nov;22(11):415-20
pubmed: 1087985
Sci Rep. 2017 Mar 20;7:44642
pubmed: 28317911
J Neurosci. 2009 Feb 18;29(7):2089-102
pubmed: 19228962
J Neuroinflammation. 2012 Dec 17;9:270
pubmed: 23244217