Streptozocin; a GLUT2 binding drug, interacts with human serum albumin at loci h6

Binding Sites Entropy Glucose Transporter Type 2 / metabolism Humans Hydrogen-Ion Concentration Protein Binding Serum Albumin, Human / chemistry Streptozocin / metabolism
Fluorescence spectroscopy Glucopyranose Human serum albumin Molecular dynamics Quenching Streptozocin

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 May 2019
Historique:
received: 22 09 2018
revised: 31 01 2019
accepted: 31 01 2019
pubmed: 5 2 2019
medline: 20 6 2019
entrez: 5 2 2019
Statut: ppublish

Résumé

Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence quenching of HSA has been done at pH 7.4, pH 3.5 and at pH 7.4 with 4.5 M urea at temperatures 286 K, 291 K, and 306 K. K

Identifiants

DOI: 10.1016/j.ijbiomac.2019.01.217 PMID: 30716368
pubmed: 30716368
pii: S0141-8130(18)35074-8
doi: 10.1016/j.ijbiomac.2019.01.217
pii:
doi:

Substances chimiques

Glucose Transporter Type 2 0
Streptozocin 5W494URQ81
Serum Albumin, Human ZIF514RVZR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

923-933

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Amogh S Deshpande (AS)

Department of Biotechnology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore 632014, India.

Sriroopreddy Ramireddy (S)

Department of Biotechnology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore 632014, India.

C Sudandiradoss (C)

Department of Biotechnology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore 632014, India.

Ayesha Noor (A)

Centre for Bioseparation Technology, Vellore Institute of Technology, Vellore 632014, India.

Priyankar Sen (P)

Centre for Bioseparation Technology, Vellore Institute of Technology, Vellore 632014, India. Electronic address: priyankar.sen@vit.ac.in.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Entropie › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de glucose par diffusion facilitée › Transporteur de glucose de type 2 › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérum-albumine humaine › Streptozocin; a GLUT2 binding drug, interacts...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Streptozocine › Streptozocin; a GLUT2 binding drug, interacts...