Breakpoint to MIC quotient: A parameter to rapidly evaluate the in vitro bactericidal activity of β-lactams on Enterobacteriaceae.
Breakpoint to MIC quotient
Enterobacteriaceae
Etest
European Committee on Antimicrobial Susceptibility Testing
Minimum Bactericidal Concentration
Minimum Inhibitory Concentration
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
10
12
2018
revised:
23
01
2019
accepted:
27
01
2019
pubmed:
5
2
2019
medline:
9
8
2019
entrez:
5
2
2019
Statut:
ppublish
Résumé
Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) do not completely predict the bactericidal nature of the antimicrobial agent. Patients with pathogens having MICs near the clinical breakpoint experience a higher risk of clinical failure. This study defined an indicator, breakpoint to MIC quotient (BMQ), that incorporates MIC and the European Committee on Antimicrobial Susceptibility Testing breakpoint. The BMQ was inversely correlated with MBC in antibiotic combinations against Enterobacteriaceae strains (Spearman coefficient ≤ -0.96). This new parameter may provide timely additional insight for choosing an antibiotic for a severe bacterial infection.
Identifiants
pubmed: 30716447
pii: S0924-8579(19)30020-2
doi: 10.1016/j.ijantimicag.2019.01.013
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactams
0
Types de publication
Journal Article
Langues
eng
Pagination
674-677Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.