Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.
Aging
Cognitive aging
Cue mismatch/double rotation
Hippocampal computation
Memory
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
05
09
2018
revised:
14
12
2018
accepted:
27
12
2018
pubmed:
5
2
2019
medline:
18
12
2019
entrez:
5
2
2019
Statut:
ppublish
Résumé
Similar to elderly humans, aged outbred Long-Evans rats exhibit individual differences in memory abilities, including a subset of aged rats that maintain memory function on par with young adults. Such individuals provide a basis for investigating mechanisms of resilience to age-related decline. The present study examined hippocampal gene expression in young adults and aged rats with preserved memory function under behavioral task conditions well established for assessing information processing central to the formation of episodic memory. Although behavioral measures and hippocampal gene induction associated with neural activity and synaptic plasticity were similar across age groups, a marker for inhibitory interneuron function in the hippocampal formation was distinctively increased only in aged rats but not in young adults. Because heightened hippocampal neural activity is associated with age-related memory impairment across species, including rats, monkeys, and humans, this finding may represent an adaptive homeostatic adjustment necessary to maintain neural plasticity and memory function in aging.
Identifiants
pubmed: 30716540
pii: S0197-4580(18)30455-X
doi: 10.1016/j.neurobiolaging.2018.12.015
pmc: PMC6392444
mid: NIHMS1520582
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-161Subventions
Organisme : NIA NIH HHS
ID : P01 AG009973
Pays : United States
Organisme : NIH HHS
ID : S10 OD020152
Pays : United States
Organisme : NIH HHS
ID : S10 OD021567
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG027668
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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