Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization.
bioactive glass
composite fibres
electrospinning
poly(lactic acid) (PLLA)
scaffolds
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
01 Feb 2019
01 Feb 2019
Historique:
received:
15
12
2018
revised:
25
01
2019
accepted:
28
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
6
2
2019
Statut:
epublish
Résumé
Efforts in tissue engineering aim at creating scaffolds that mimic the physiological environment with its structural, topographical and mechanical properties for restoring the function of damaged tissue. In this study we introduce composite fibres made by a biodegradable poly(lactic acid) (PLLA) matrix embedding bioactive silica-based glass particles (SBA2). Electrospinning is performed to achieve porous PLLA filaments with uniform dispersion of bioactive glass powder. The obtained composite fibres show in aligned arrays significantly increased elastic modulus compared with that of neat polymer fibres during uniaxial tensile stress. Additionally, the SBA2 bioactivity is preserved upon encapsulation as highlighted by the promoted deposition of hydroxycarbonate apatite (HCA) upon immersion in simulated body fluid solutions. HCA formation is sequential to earlier processes of polymer erosion and ion release leading to acidification of the surrounding solution environment. These findings suggest PLLA-SBA2 fibres as a composite, multifunctional system which might be appealing for both bone and soft tissue engineering applications.
Identifiants
pubmed: 30717161
pii: nano9020182
doi: 10.3390/nano9020182
pmc: PMC6410207
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Calcif Tissue Int. 2000 Oct;67(4):321-9
pubmed: 11000347
Biochem Biophys Res Commun. 2000 Sep 24;276(2):461-5
pubmed: 11027497
Biomaterials. 2000 Dec;21(24):2529-43
pubmed: 11071603
J Biomed Mater Res. 2001 May;55(2):151-7
pubmed: 11255166
J Biomed Mater Res A. 2003 Jan 1;64(1):189-95
pubmed: 12483713
Biomaterials. 2003 May;24(12):2077-82
pubmed: 12628828
Biomaterials. 2003 Jun;24(13):2133-51
pubmed: 12699650
Biomaterials. 2003 Nov;24(24):4353-64
pubmed: 12922148
Biomaterials. 2004 Feb;25(5):877-86
pubmed: 14609676
J Biomed Mater Res A. 2003 Dec 15;67(4):1401-11
pubmed: 14624528
Biomaterials. 2004 Jun;25(13):2489-500
pubmed: 14751733
Biomaterials. 2004 Aug;25(18):4185-94
pubmed: 15046908
Biomaterials. 2004 Dec;25(27):5857-66
pubmed: 15172498
J Mater Sci Mater Med. 2004 Apr;15(4):419-22
pubmed: 15332610
Biomaterials. 2005 May;26(14):1665-74
pubmed: 15576140
Biomaterials. 2005 May;26(15):2603-10
pubmed: 15585263
J Biomed Mater Res A. 2005 Apr 1;73(1):73-9
pubmed: 15714504
Biomaterials. 2005 Sep;26(27):5474-91
pubmed: 15860204
Tissue Eng. 2005 May-Jun;11(5-6):768-77
pubmed: 15998217
J Membr Biol. 2005 Jun;205(3):129-37
pubmed: 16362501
Biomaterials. 2006 May;27(15):2907-15
pubmed: 16448693
Biomaterials. 2006 Jun;27(18):3413-31
pubmed: 16504284
J Am Chem Soc. 2007 Mar 14;129(10):2777-82
pubmed: 17302411
Biomaterials. 2008 Apr;29(12):1750-61
pubmed: 18255139
Biomaterials. 2008 May;29(13):1989-2006
pubmed: 18281090
Artif Organs. 2008 May;32(5):388-97
pubmed: 18471168
Nat Nanotechnol. 2007 Jan;2(1):59-62
pubmed: 18654209
J Biomed Mater Res B Appl Biomater. 2009 Oct;91(1):213-20
pubmed: 19422050
J Mater Sci Mater Med. 2009 Nov;20(11):2189-95
pubmed: 19488679
Acta Biomater. 2010 Jan;6(1):90-101
pubmed: 19631769
Acta Biomater. 2010 Mar;6(3):812-9
pubmed: 19770078
Langmuir. 2010 Dec 7;26(23):18340-8
pubmed: 21050002
Biomaterials. 2011 Apr;32(11):2757-74
pubmed: 21292319
Acta Biomater. 2011 Jun;7(6):2355-73
pubmed: 21421084
Biomed Mater. 2012 Jun;7(3):035010
pubmed: 22477772
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Adv Healthc Mater. 2012 Jan 11;1(1):10-25
pubmed: 23184683
Biotechnol Adv. 2013 Sep-Oct;31(5):669-87
pubmed: 23195284
Bone Joint J. 2014 Jun;96-B(6):845-50
pubmed: 24891588
Macromolecules. 2014 Jul 22;47(14):4704-4710
pubmed: 25067856
Mater Sci Eng C Mater Biol Appl. 2014 Oct;43:65-75
pubmed: 25175189
Acta Biomater. 2015 Feb;13:1-15
pubmed: 25462853
Biomaterials. 2015;53:379-91
pubmed: 25890736
Bone Res. 2013 Sep 25;1(3):216-48
pubmed: 26273505
Biomed Mater. 2015 Oct 20;10(5):055014
pubmed: 26481324
Nanomaterials (Basel). 2016 Apr 15;6(4):
pubmed: 28335202
Acta Biomater. 2017 Jun;55:249-261
pubmed: 28377306
Materials (Basel). 2018 Mar 08;11(3):null
pubmed: 29517988
Am J Physiol. 1984 Apr;246(4 Pt 2):R409-38
pubmed: 6326601