HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses.
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Down-Regulation
HIV-1
/ growth & development
Host-Pathogen Interactions
Human Immunodeficiency Virus Proteins
/ metabolism
Humans
Immune Evasion
Immunity, Innate
NF-kappa B
/ antagonists & inhibitors
Transcription, Genetic
Viral Regulatory and Accessory Proteins
/ metabolism
HIV-1
NF-κB
RNA-Seq
Vpu
human
immune activation
immunology
infectious disease
inflammation
microbiology
tetherin
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
11
09
2018
accepted:
26
01
2019
pubmed:
6
2
2019
medline:
27
3
2020
entrez:
6
2
2019
Statut:
epublish
Résumé
Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activation of the transcription factor NF-κB. Global transcriptional profiling of infected CD4 +T cells revealed that
Identifiants
pubmed: 30717826
doi: 10.7554/eLife.41930
pii: 41930
pmc: PMC6372280
doi:
pii:
Substances chimiques
Human Immunodeficiency Virus Proteins
0
NF-kappa B
0
Viral Regulatory and Accessory Proteins
0
vpu protein, Human immunodeficiency virus 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SPP 1923
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : 404687549
Pays : International
Informations de copyright
© 2019, Langer et al.
Déclaration de conflit d'intérêts
SL, CH, KH, LK, DH, PD, KH, LP, NS, Jv, SC, JF, FK, DS No competing interests declared
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