CD4 receptor diversity in chimpanzees protects against SIV infection.

Animals CD4 Antigens / genetics CD4-Positive T-Lymphocytes / immunology Evolution, Molecular Genetic Variation / immunology HIV / genetics Humans Pan troglodytes / genetics Polysaccharides / genetics Simian Acquired Immunodeficiency Syndrome / genetics Simian Immunodeficiency Virus / genetics Viral Envelope Proteins / genetics
CD4 SIV chimpanzee envelope glycoprotein glycan restriction

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
19 02 2019
Historique:
pubmed: 6 2 2019
medline: 2 5 2019
entrez: 6 2 2019
Statut: ppublish

Résumé

Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine coding variants present in wild populations, and that this diversity interferes with SIV envelope (Env)-CD4 interactions. Testing the replication fitness of SIVcpz strains in CD4

Identifiants

DOI: 10.1073/pnas.1821197116 PMID: 30718403 PMC: PMC6386711
pubmed: 30718403
pii: 1821197116
doi: 10.1073/pnas.1821197116
pmc: PMC6386711
doi:

Substances chimiques

CD4 Antigens 0
Polysaccharides 0
Viral Envelope Proteins 0

Banques de données

GENBANK
['MK178722', 'MK178852', 'MK208828', 'MK208836', 'MK208839', 'MK208845']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3229-3238

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007632
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI050529
Pays : United States
Organisme : CIHR
ID : 352417
Pays : Canada
Organisme : NIAID NIH HHS
ID : R37 AI150590
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120810
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI091595
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050529
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI058715
Pays : United States
Organisme : NIH HHS
ID : P51 OD011133
Pays : United States
Organisme : NIAID NIH HHS
ID : R61 AI133696
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR000165
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131331
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI091516
Pays : United States
Organisme : NIAID NIH HHS
ID : R33 AI133696
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI144371
Pays : United States
Organisme : NCRR NIH HHS
ID : P51 RR013986
Pays : United States

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Frederic Bibollet-Ruche (F)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Ronnie M Russell (RM)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Weimin Liu (W)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Guillaume B E Stewart-Jones (GBE)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Scott Sherrill-Mix (S)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Yingying Li (Y)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Gerald H Learn (GH)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Andrew G Smith (AG)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Marcos V P Gondim (MVP)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Lindsey J Plenderleith (LJ)

Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.
Centre for Immunity, Infection and Evolution, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.
ORCID: 0000-0003-1941-2876

Julie M Decker (JM)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.

Juliet L Easlick (JL)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Katherine S Wetzel (KS)

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Ronald G Collman (RG)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Shilei Ding (S)

Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal, QC H2X0A9, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.

Andrés Finzi (A)

Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du Centre Hospitalier de L'Université de Montréal, Montréal, QC H2X0A9, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X0A9, Canada.

Ahidjo Ayouba (A)

Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34090 Montpellier, France.

Martine Peeters (M)

Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, 34090 Montpellier, France.

Fabian H Leendertz (FH)

Research Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353 Berlin, Germany.

Joost van Schijndel (J)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Chimbo Foundation, 1011 PW Amsterdam, The Netherlands.

Annemarie Goedmakers (A)

Chimbo Foundation, 1011 PW Amsterdam, The Netherlands.

Els Ton (E)

Chimbo Foundation, 1011 PW Amsterdam, The Netherlands.

Christophe Boesch (C)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
ORCID: 0000-0001-9538-7858

Hjalmar Kuehl (H)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

Mimi Arandjelovic (M)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

Paula Dieguez (P)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

Mizuki Murai (M)

Department of Primatology, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.

Christelle Colin (C)

Projet Primates France, Centre de Conservation pour Chimpanzés, BP 36 Faranah, Republic of Guinea.

Kathelijne Koops (K)

Department of Anthropology, University of Zurich, CH-8006 Zurich, Switzerland.

Sheri Speede (S)

Sanaga-Yong Chimpanzee Rescue Center, In Defense of Animals-Africa, Portland, OR 97204.

Mary K Gonder (MK)

Department of Biology, Drexel University, Philadelphia, PA 19104.
ORCID: 0000-0003-4190-4682

Martin N Muller (MN)

Department of Anthropology, University of New Mexico, Albuquerque, NM 87131.

Crickette M Sanz (CM)

Department of Anthropology, Washington University in St. Louis, St Louis, MO 63130.
Congo Program, Wildlife Conservation Society, BP 14537 Brazzaville, Republic of the Congo.

David B Morgan (DB)

Congo Program, Wildlife Conservation Society, BP 14537 Brazzaville, Republic of the Congo.
Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, Chicago, IL 60614.

Rebecca Atencia (R)

Tchimpounga Chimpanzee Rehabilitation Center, The Jane Goodall Institute-Congo, BP 1206 Pointe Noire, Republic of Congo.

Debby Cox (D)

Tchimpounga Chimpanzee Rehabilitation Center, The Jane Goodall Institute-Congo, BP 1206 Pointe Noire, Republic of Congo.
Africa Programs, The Jane Goodall Institute, Vienna, VA 22182.

Alex K Piel (AK)

School of Natural Sciences and Psychology, Liverpool John Moores University, L3 3AF Liverpool, United Kingdom.

Fiona A Stewart (FA)

School of Natural Sciences and Psychology, Liverpool John Moores University, L3 3AF Liverpool, United Kingdom.

Jean-Bosco N Ndjango (JN)

Department of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani, BP 2012 Kisangani, Democratic Republic of the Congo.

Deus Mjungu (D)

Gombe Stream Research Centre, The Jane Goodall Institute, Kigoma, Tanzania.

Elizabeth V Lonsdorf (EV)

Department of Psychology, Franklin and Marshall College, Lancaster, PA 17604.

Anne E Pusey (AE)

Department of Evolutionary Anthropology, Duke University, Durham, NC 27708.

Peter D Kwong (PD)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
ORCID: 0000-0003-3560-232X

Paul M Sharp (PM)

Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.
Centre for Immunity, Infection and Evolution, University of Edinburgh, EH9 3FL Edinburgh, United Kingdom.

George M Shaw (GM)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Beatrice H Hahn (BH)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104; bhahn@pennmedicine.upenn.edu.
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD4 › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Pan troglodytes › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Glucides › Polyosides › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Maladies de l'animal › Maladies des primates › Maladies des singes › Syndrome d'immunodéficience acquise du singe › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Rétrovirus simiens › Virus de l'immunodéficience simienne › CD4 receptor diversity in chimpanzees protects...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › CD4 receptor diversity in chimpanzees protects...