Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.
Biological Specimen Banks
Cohort Studies
Depression
/ etiology
Depressive Disorder, Major
/ etiology
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Life Change Events
Male
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Regression Analysis
Scotland
United Kingdom
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
04 02 2019
04 02 2019
Historique:
received:
26
11
2018
accepted:
10
12
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10
Identifiants
pubmed: 30718454
doi: 10.1038/s41398-018-0360-y
pii: 10.1038/s41398-018-0360-y
pmc: PMC6361928
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14Subventions
Organisme : Chief Scientist Office
ID : CZD/16/6
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109528
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom
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