Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
04 02 2019
04 02 2019
Historique:
received:
22
05
2018
accepted:
17
01
2019
revised:
26
12
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
21
6
2019
Statut:
epublish
Résumé
Childhood psychotic experiences (PEs), such as seeing or hearing things that others do not, or extreme paranoia, are relatively common with around 1 in 20 children reporting them at age 12. Childhood PEs are often distressing and can be predictive of schizophrenia, other psychiatric disorders, and suicide attempts in adulthood, particularly if they persist during adolescence. Previous research has demonstrated that methylomic signatures in blood could be potential biomarkers of psychotic phenomena. This study explores the association between DNA methylation (DNAm) and the emergence, persistence, and remission of PEs in childhood and adolescence. DNAm profiles were obtained from the ALSPAC cohort at birth, age 7, and age 15/17 (n = 901). PEs were assessed through interviews with participants at ages 12 and 18. We identified PE-associated probes (p < 5 × 10
Identifiants
pubmed: 30718501
doi: 10.1038/s41398-019-0407-8
pii: 10.1038/s41398-019-0407-8
pmc: PMC6361958
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
69Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBI025751/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/9
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/4
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I025263/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/8
Pays : United Kingdom
Références
Int J Epidemiol. 2015 Aug;44(4):1181-90
pubmed: 25991711
Psychol Med. 2013 Oct;43(10):2077-86
pubmed: 23302254
Arch Gen Psychiatry. 2010 Apr;67(4):328-38
pubmed: 20368509
BMC Bioinformatics. 2017 Apr 14;18(1):216
pubmed: 28410574
Mol Psychiatry. 2018 Mar;23(3):639-647
pubmed: 28115744
Clin Genet. 2013 Jun;83(6):511-7
pubmed: 23379509
Neuropharmacology. 2016 Jan;100:27-39
pubmed: 26275848
Epigenetics. 2015;10(11):1024-32
pubmed: 26457534
J Child Psychol Psychiatry. 2002 Sep;43(6):727-42
pubmed: 12236608
Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):477-83
pubmed: 22488909
BMC Genet. 2016 Jan 25;17:27
pubmed: 26809779
Genome Biol. 2016 Aug 30;17(1):176
pubmed: 27572077
PLoS One. 2013 May 17;8(5):e63812
pubmed: 23691101
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Am J Hum Genet. 2008 Mar;82(3):696-711
pubmed: 18319075
Hum Mol Genet. 2011 Dec 15;20(24):4786-96
pubmed: 21908516
Genome Biol. 2014;15(10):483
pubmed: 25347937
Clin Epigenetics. 2014 Feb 03;6(1):4
pubmed: 24485148
Am J Psychiatry. 2013 Jul;170(7):742-50
pubmed: 23639948
Int J Eat Disord. 2015 Nov;48(7):874-82
pubmed: 25808061
JAMA Psychiatry. 2013 Sep;70(9):940-8
pubmed: 23863946
Arch Gen Psychiatry. 2000 Nov;57(11):1053-8
pubmed: 11074871
J Psychosom Res. 2017 Jan;92:34-44
pubmed: 27998510
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Biol Mood Anxiety Disord. 2012 Jun 14;2:10
pubmed: 22738307
Nucleic Acids Res. 2015 Jan;43(Database issue):D1049-56
pubmed: 25428369
JAMA Psychiatry. 2014 Mar;71(3):255-64
pubmed: 24402055
Genome Biol. 2012 Jun 15;13(6):R43
pubmed: 22703893
Am J Epidemiol. 2016 Jun 15;183(12):1149-58
pubmed: 27188935
Eur J Hum Genet. 2015 Aug;23(8):1106-10
pubmed: 25424713
Transl Psychiatry. 2014 Jan 07;4:e339
pubmed: 24399042
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Am J Psychiatry. 2018 Jun 1;175(6):517-529
pubmed: 29325449
Dialogues Clin Neurosci. 2014 Sep;16(3):395-404
pubmed: 25364288
Br J Psychiatry. 2008 Sep;193(3):185-91
pubmed: 18757973
Hum Mol Genet. 2017 Jan 1;26(1):210-225
pubmed: 28011714
BMC Genomics. 2014 Jan 22;15:51
pubmed: 24447442
Schizophr Bull. 2011 Jan;37(1):84-93
pubmed: 19460881
Bioinformatics. 2018 Dec 1;34(23):3983-3989
pubmed: 29931280
Depress Anxiety. 2013 Dec;30(12):1151-60
pubmed: 23959810
Genome Biol. 2016 May 03;17:84
pubmed: 27142380
Schizophr Bull. 2018 Feb 15;44(2):348-358
pubmed: 28535284
Biol Psychiatry. 2011 Jan 15;69(2):146-56
pubmed: 20510393
Acta Psychiatr Scand. 2016 Jul;134(1):6-15
pubmed: 27009572
Schizophr Bull. 2010 Nov;36(6):1157-66
pubmed: 19429845
Epigenetics. 2015;10(11):1014-23
pubmed: 26479702
Mol Psychiatry. 2017 Apr;22(4):512-518
pubmed: 27113994
Front Neurol. 2015 May 26;6:107
pubmed: 26074864
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
J Hum Genet. 2013 Feb;58(2):91-7
pubmed: 23235336
BMC Genomics. 2013 May 01;14:293
pubmed: 23631413