An Implantable Ultrasonically-Powered Micro-Light-Source (µLight) for Photodynamic Therapy.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 02 2019
04 02 2019
Historique:
received:
23
10
2018
accepted:
10
12
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
19
8
2020
Statut:
epublish
Résumé
Photodynamic therapy (PDT) is a promising cancer treatment modality that can selectively target unresectable tumors through optical activation of cytotoxic agents, thus reducing many side effects associated with systemic administration of chemotherapeutic drugs. However, limited light penetration into most biological tissues have so far prevented its widespread adoption beyond dermatology and a few other oncological applications in which a fiber optic can be threaded to the desired locations via an endoscopic approach (e.g., bladder). In this paper, we introduce an ultrasonically powered implantable microlight source, μLight, which enables in-situ localized light delivery to deep-seated solid tumors. Ultrasonic powering allows for small receiver form factor (mm-scale) and power transfer deep into the tissue (several centimeters). The implants consist of piezoelectric transducers measuring 2 × 2 × 2 mm
Identifiants
pubmed: 30718792
doi: 10.1038/s41598-019-38554-2
pii: 10.1038/s41598-019-38554-2
pmc: PMC6362227
doi:
Substances chimiques
Photosensitizing Agents
0
Verteporfin
0X9PA28K43
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1395Subventions
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
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