Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses.

Adaptation, Psychological / physiology Animals Anxiety / physiopathology CA3 Region, Hippocampal / physiology Conditioning, Classical Dentate Gyrus / physiology Discrimination, Psychological / physiology Fear / physiology Freezing Reaction, Cataleptic Interneurons / metabolism Male Mice Neural Pathways / physiology Optogenetics Septal Nuclei / metabolism Somatostatin / metabolism

Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
03 2019
Historique:
received: 22 08 2017
accepted: 17 12 2018
pubmed: 6 2 2019
medline: 22 5 2019
entrez: 6 2 2019
Statut: ppublish

Résumé

Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly coactivated ensembles following contextual fear discrimination identified the dorsolateral septum (DLS) as a relay of the dentate gyrus-CA3 circuit. Retrograde monosynaptic tracing and electrophysiological whole-cell recordings demonstrated that DLS somatostatin-expressing interneurons (SST-INs) receive direct CA3 inputs. Longitudinal in vivo calcium imaging of DLS SST-INs in awake, behaving mice identified a stable population of footshock-responsive SST-INs during contextual conditioning whose activity tracked and predicted non-freezing epochs during subsequent recall in the training context but not in a similar, neutral context or open field. Optogenetic attenuation or stimulation of DLS SST-INs bidirectionally modulated conditioned fear responses and recruited proximal and distal subcortical targets. Together, these observations suggest a role for a potentially hard-wired DLS SST-IN subpopulation as arbiters of mobility that calibrate context-appropriate behavioral fear responses.

Identifiants

DOI: 10.1038/s41593-018-0330-y PMID: 30718902 PMC: PMC6387640
pubmed: 30718902
doi: 10.1038/s41593-018-0330-y
pii: 10.1038/s41593-018-0330-y
pmc: PMC6387640
mid: NIHMS1516898
doi:

Substances chimiques

Somatostatin 51110-01-1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

436-446

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH104175
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111729
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG048908
Pays : United States

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Auteurs

Antoine Besnard (A)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.
ORCID: 0000-0002-0929-8873

Yuan Gao (Y)

Department of Biology, Boston University, Boston, MA, USA.

Michael TaeWoo Kim (M)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.

Hannah Twarkowski (H)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.

Alexander Keith Reed (AK)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.

Tomer Langberg (T)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.

Wendy Feng (W)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard Stem Cell Institute, Cambridge, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA.

Xiangmin Xu (X)

Departments of Anatomy and Neurobiology and Biomedical Engineering, School of Medicine, University of California, Irvine, CA, USA.

Dieter Saur (D)

Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, Germany.
Institute of Translational Cancer Research and Experimental Cancer Therapy, and Department of Medicine II, Technische Universität Munchen, Munich, Germany.

Larry S Zweifel (LS)

Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA.

Ian Davison (I)

Department of Biology, Boston University, Boston, MA, USA.

Amar Sahay (A)

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. asahay@mgh.harvard.edu.
Harvard Stem Cell Institute, Cambridge, MA, USA. asahay@mgh.harvard.edu.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. asahay@mgh.harvard.edu.
BROAD Institute of Harvard and MIT, Cambridge, MA, USA. asahay@mgh.harvard.edu.
ORCID: 0000-0003-0677-1693

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Adaptation psychologique › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Eucaryotes › Animaux › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Région CA3 de l'hippocampe › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Conditionnement (psychologie) › Conditionnement classique › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Gyrus denté › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Discrimination (psychologie) › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Peur › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Réaction de catalepsie › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Optogénétique › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Septum du cerveau › Noyaux du septum › Dorsolateral septum somatostatin interneurons...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypothalamiques hypophysotropes inhibitrices › Somatostatine › Dorsolateral septum somatostatin interneurons...