Dendritic cell subpopulations in nasopharyngeal cancer.
C-lectin receptor
antigen presentation
langerin
pattern recognition receptor
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
04
2018
accepted:
17
09
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
6
2
2019
Statut:
ppublish
Résumé
Nasopharyngeal cancer (NPC) is associated with Epstein-Barr virus (EBV) and EBV antigen may be utilized for therapeutic purposes, including targeting of dendritic cells (DCs). Although DCs may be present in NPC, the information is limited and not up-to-date with current knowledge on DC subsets. In the present study, biopsies from untreated NPC were obtained and subjected to multicolor flow-cytometry focusing on DC subtype markers: CD123 for plasmacytoid DCs (pDCs); and CD1c and CD141 for myeloid DCs (mDCs). Furthermore, subset-specific expression of the C-lectin receptor (CLR) CD207 (also termed langerin) was assessed. pDCs and mDCs were detected in the NPC lesions, contributing to a frequency mean average of 0.78% of CD45
Identifiants
pubmed: 30719121
doi: 10.3892/ol.2018.9835
pii: OL-0-0-9835
pmc: PMC6350184
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2557-2561Références
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