Heterogeneity in risk factors for ductal and lobular breast carcinomas: A case-control study.
Abortion, Spontaneous
/ epidemiology
Adult
Breast Feeding
/ statistics & numerical data
Breast Neoplasms
/ epidemiology
Carcinoma, Ductal, Breast
/ epidemiology
Carcinoma, Lobular
/ epidemiology
Case-Control Studies
Diabetes Mellitus, Type 2
/ epidemiology
Female
Humans
Iran
Middle Aged
Risk Factors
ductal breast carcinoma
epidemiology
heterogeneity
lobular breast carcinoma
risk factors
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
25
07
2018
revised:
21
12
2018
accepted:
16
01
2019
pubmed:
6
2
2019
medline:
1
2
2020
entrez:
6
2
2019
Statut:
ppublish
Résumé
Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast are the most common histological subtypes of breast cancer. However, the associations and heterogeneity between histological subtypes and their risk factors are not well established. This study aimed to investigate risk factors for IDC and ILC. This case-control study included 1,009 incident breast cancer cases and 1,009 hospital controls, frequency-matched by age. Data were obtained from the patients' medical files and an interview administered via a questionnaire. Multinomial logistic regression was used and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The heterogeneity of the associations was assessed using the Wald test. Family history of breast cancer was associated with IDC (OR 2.64, 95% CI: 1.97-3.55) but not ILC (OR 0.81, 95% CI: 0.42-1.57; p for heterogeneity <0.001). Conversely, a history of miscarriage was associated with ILC (OR 1.71, 95% CI: 1.17-2.51) but not IDC (OR 1.18, 95% CI: 0.95-1.46; p for heterogeneity = 0.04). Similarly, type 2 diabetes was associated with ILC but not IDC (p for heterogeneity = 0.02). Age at first delivery and breastfeeding were significantly associated with IDC but not ILC, though p values for heterogeneity did not reach the significance level. Deliberate weight loss and age at menarche were significantly associated with ILC but not IDC (p for heterogeneity ≥0.27). Smoking, history of benign breast disease and BMI were associated with both subtypes. The present study supports the hypothesis that IDC and ILC are etiologically distinct tumours.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2917-2925Informations de copyright
© 2019 UICC.
Références
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin 2018;68:7-30.
Hashim D, Boffetta P, La Vecchia C, et al. The global decrease in cancer mortality: trends and disparities. Ann Oncol 2016;27:926-33.
Dianatinasab M, Mohammadianpanah M, Daneshi N, et al. Socioeconomic factors, health behavior, and late-stage diagnosis of breast cancer: considering the impact of delay in diagnosis. Clin Breast Cancer 2018;18:239-45.
Dianatinasab M, Fararouei M, Mohammadianpanah M, et al. Hair coloring, stress, and smoking increase the risk of breast cancer: a case-control study. Clin Breast Cancer 2017;17:650-9.
Alipour S, Modirian M, Etemad K. National and sub-national burden of breast cancer in Iran; 1990-2013. Arch Iran Med 2014;17:794-9.
Makki J. Diversity of breast carcinoma: histological subtypes and clinical relevance. Clin Med Insights Pathol 2015;8:23-31.
Najafi B, Anvari S, Roshan ZA. Disease free survival among molecular subtypes of early stage breast cancer between 2001 and 2010 in Iran. Asian Pac J Cancer Prev 2013;14:5811-6.
Kotsopoulos J, Chen WY, Gates MA, et al. Risk factors for ductal and lobular breast cancer: results from the nurses' health study. Breast Cancer Res 2010;12:R106.
Cocquyt V, Van Belle S. Lobular carcinoma in situ and invasive lobular cancer of the breast. Curr Opin Obstet Gynecol 2005;17:55-60.
Mullooly M, Khodr ZG, Dallal CM, et al. Epidemiologic risk factors for in situ and invasive breast cancers among postmenopausal women in the National Institutes of Health-AARP diet and health study. Am J Epidemiol 2017;186:1329-40.
Ursin G, Bernstein L, Lord SJ, et al. Reproductive factors and subtypes of breast cancer defined by hormone receptor and histology. Br J Cancer 2005;93:364-71.
Williams LA, Nichols HB, Hoadley KA, et al. Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina breast cancer study. Cancer Causes Control 2018;1:25-32.
Daroudi R, Sari AA, Nahvijou A, et al. The economic burden of breast cancer in Iran. Iran J Public Health 2015;44:1225-33.
Cancer CGoHFiB. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 2012;13:1141-51.
Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.
Baglia ML, Cook LS, Mei-Tzu C, et al. Alcohol, smoking, and risk of Her2-overexpressing and triple-negative breast cancer relative to estrogen receptor-positive breast cancer. Int J Cancer 2018;143:1849-57.
Pacheco SO, Pacheco FJ, Zapata GM, et al. Food habits, lifestyle factors, and risk of prostate cancer in Central Argentina: a case control study involving self-motivated health behavior modifications after diagnosis. Nutrients 2016;8:1-22.
Hruby A, Manson JE, Qi L, et al. Determinants and consequences of obesity. Am J Public Health 2016;106:1656-62.
Fallahzadeh H. Age at natural menopause in Yazd, Islamic Republic of Iran. Menopause (New York, NY) 2007;14:900-4.
Mohammad K, Sadat Hashemi SM, Farahani FK. Age at natural menopause in Iran. Maturitas 2004;49:321-6.
Njiaju UO, Olopade OI. Genetic determinants of breast cancer risk: a review of current literature and issues pertaining to clinical application. Breast J 2012;18:436-42.
Phipps AI, Li CI, Kerlikowske K, et al. Risk factors for ductal, lobular, and mixed ductal-lobular breast cancer in a screening population. Cancer Epidemiol Biomarkers Prev 2010;19:1643-54.
Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer 2007;121:856-62.
Michels KB, Solomon CG, Hu FB, et al. Type 2 diabetes and subsequent incidence of breast cancer in the nurses’ health study. Diabetes Care 2003;26:1752-8.
Chappell J, Leitner JW, Solomon S, et al. Effect of insulin on cell cycle progression in MCF-7 breast cancer cells direct and potentiating influence. J Biol Chem 2001;276:38023-8.
Papa V, Belfiore A. Insulin receptors in breast cancer: biological and clinical role. J Endocrinol Invest 1996;19:324-33.
Kaaks R, Berrino F, Key T, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer Inst 2005;97:755-65.
Key T, Appleby P, Barnes I, et al. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94:606-16.
Reeves GK, Pirie K, Green J, et al. Reproductive factors and specific histological types of breast cancer: prospective study and meta-analysis. Br J Cancer 2009;100:538-44.
Ghiasvand R, Maram ES, Tahmasebi S, et al. Risk factors for breast cancer among young women in southern Iran. Int J Cancer 2011;129:1443-9.
Michels KB, Willett WC, Rosner BA, et al. Prospective assessment of breastfeeding and breast cancer incidence among 89,887 women. Lancet 1996;347:431-6.
Kwan ML, Kushi LH, Weltzien E, et al. Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res 2009;11:R31-R.
Butt S, Borgquist S, Anagnostaki L, et al. Breastfeeding in relation to risk of different breast cancer characteristics. BMC Res Notes 2014;7:216.
Gaudet MM, Gapstur SM, Sun J, et al. Active smoking and breast cancer risk: original cohort data and meta-analysis. J Natl Cancer Inst 2013;105:515-25.
Terry PD, Rohan TE. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol Biomarkers Prev 2002;11:953-71.
Lankarani KB, Afshari R. Alcohol consumption in Iran. Lancet 2014;384:1927-8.
Rosenberg LU, Magnusson C, Lindstrom E, et al. Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: a case-control study. Breast Cancer Res 2006;8:R11.
Newcomer LM, Newcomb PA, Trentham-Dietz A, et al. Oral contraceptive use and risk of breast cancer by histologic type. Int J Cancer 2003;106:961-4.
Li CI, Malone KE, Porter PL, et al. Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65-79 years of age. Int J Cancer 2003;107:647-51.
Park YM, White AJ, Nichols HB, et al. The association between metabolic health, obesity phenotype and the risk of breast cancer. Int J Cancer 2017;140:2657-66.
Balekouzou A, Yin P, Pamatika CM, et al. Reproductive risk factors associated with breast cancer in women in Bangui: a case-control study. BMC Womens Health 2017;17:1-9.
Hardefeldt PJ, Penninkilampi R, Edirimanne S, et al. Physical activity and weight loss reduce the risk of breast cancer: a meta-analysis of 139 prospective and retrospective studies. Clin Breast Cancer 2018;18:e601-12.
Albrektsen G, Heuch I, Thoresen SO. Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway. BMC Cancer 2010;10:226-36.
Newcomb P, Trentham-Dietz A, Hampton J, et al. Late age at first full term birth is strongly associated with lobular breast cancer. Cancer 2011;117:1946-56.
Li H, Sun X, Miller E, et al. BMI, reproductive factors, and breast cancer molecular subtypes: a case-control study and meta-analysis. J Epidemiol 2017;27:143-51.
Kapil U, Bhadoria A, Sareen N, et al. Reproductive factors and risk of breast cancer: a review. Indian J Cancer 2014;51:571-6.
Ahmed K, Asaduzzaman S, Bashar MI, et al. Association assessment among risk factors and breast cancer in a low income country: Bangladesh. Asian Pac J Cancer Prev 2015;16:7507-12.
Jia X, Liu G, Mo M, et al. Reproductive factors and hormone receptor status among very young (<35 years) breast cancer patients. Oncotarget 2015;6:24571-80.
Guo J, Huang Y, Yang L, et al. Association between abortion and breast cancer: an updated systematic review and meta-analysis based on prospective studies. Cancer Causes Control 2015;26:811-9.
Dossus L, Benusiglio PR. Lobular breast cancer: incidence and genetic and non-genetic risk factors. Breast Cancer Res: BCR 2015;17:37. https://doi.org/10.1186/s13058-015-0546-7.
Li CI, Anderson BO, Daling JR, et al. Trends in incidence rates of invasive lobular and ductal breast carcinoma. JAMA 2003;289:1421-4.