RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls.
Journal
Scientific data
ISSN: 2052-4463
Titre abrégé: Sci Data
Pays: England
ID NLM: 101640192
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
05
07
2018
accepted:
14
12
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
4
6
2019
Statut:
epublish
Résumé
Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analysis on Peripheral Blood Mononuclear Cells (PBMCs) from sporadic and mutated ALS patients (mutations in FUS, TARDBP, SOD1 and VCP genes) and healthy controls. This dataset allows the whole-transcriptome characterization of PBMCs content, both in terms of coding and non-coding RNAs, in order to compare the disease state to the healthy controls, both for sporadic patients and for mutated patients. Our dataset is a starting point for the omni-comprehensive analysis of coding and lncRNAs, from an easy to withdraw, manage and store tissue that shows to be a suitable model for RNA profiling in ALS.
Identifiants
pubmed: 30720798
pii: sdata20196
doi: 10.1038/sdata.2019.6
pmc: PMC6362931
doi:
Substances chimiques
DNA-Binding Proteins
0
FUS protein, human
0
RNA, Long Noncoding
0
RNA-Binding Protein FUS
0
SOD1 protein, human
0
TARDBP protein, human
0
Superoxide Dismutase-1
EC 1.15.1.1
VCP protein, human
EC 3.6.4.6
Valosin Containing Protein
EC 3.6.4.6
Types de publication
Dataset
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
190006Références
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