Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength.
Animals
Animals, Newborn
Bone Development
Bone Resorption
/ physiopathology
Bone and Bones
/ diagnostic imaging
Calcification, Physiologic
Calcinosis
/ diagnostic imaging
Cells, Cultured
Chondrocytes
/ metabolism
Humans
Incisor
/ ultrastructure
Mice, Inbred C57BL
Mice, Knockout
Osteoblasts
/ metabolism
Phenotype
Skull
/ diagnostic imaging
Sodium-Phosphate Cotransporter Proteins, Type III
/ deficiency
Tooth
/ growth & development
X-Ray Microtomography
ANIMAL MODELS (GENETIC ANIMAL MODELS)
BONE MATRIX (MATRIX MINERALIZATION)
DISORDERS OF CALCIUM/PHOSPHATE METABOLISM (OTHER)
GENETIC RESEARCH (HUMAN ASSOCIATION STUDIES)
ORTHOPAEDICS (BIOMECHANICS)
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
06
07
2018
revised:
22
01
2019
accepted:
26
01
2019
pubmed:
6
2
2019
medline:
7
8
2020
entrez:
6
2
2019
Statut:
ppublish
Résumé
Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2
Identifiants
pubmed: 30721528
doi: 10.1002/jbmr.3691
pmc: PMC6618161
doi:
Substances chimiques
SLC20A2 protein, human
0
Slc20a2 protein, mouse
0
Sodium-Phosphate Cotransporter Proteins, Type III
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1101-1114Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
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