Eavesdropping on the conversation between immune cells and the skin epithelium.
DETCs
Langerhans cells
epithelial immunity
regeneration and repair
regulatory T cells
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
13 07 2019
13 07 2019
Historique:
received:
12
12
2018
accepted:
04
01
2019
pubmed:
6
2
2019
medline:
31
3
2020
entrez:
6
2
2019
Statut:
ppublish
Résumé
The skin epithelium covers our body and serves as a vital interface with the external environment. Here, we review the context-specific interactions between immune cells and the epithelium that underlie barrier fitness and function. We highlight the mechanisms by which these two systems engage each other and how immune-epithelial interactions are tuned by microbial and inflammatory stimuli. Epithelial homeostasis relies on a delicate balance of immune surveillance and tolerance, breakdown of which results in disease. In addition to their canonical immune functions, resident and recruited immune cells also supply the epithelium with instructive signals to promote repair. Decoding the dialogue between immunity and the epithelium therefore has great potential for boosting barrier function or mitigating inflammatory epithelial diseases.
Identifiants
pubmed: 30721971
pii: 5307109
doi: 10.1093/intimm/dxy088
pmc: PMC6626297
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-422Subventions
Organisme : NIAID NIH HHS
ID : K22 AI135099
Pays : United States
Informations de copyright
© The Japanese Society for Immunology. 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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