A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women.

Aged Biomarkers, Tumor / blood Case-Control Studies Female Humans Metabolome Metabolomics / methods Middle Aged Pancreatic Neoplasms / metabolism Postmenopause Prospective Studies

Journal

Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409

Informations de publication

Date de publication:
04 2019
Historique:
received: 08 06 2018
revised: 12 11 2018
accepted: 29 01 2019
pubmed: 7 2 2019
medline: 14 7 2020
entrez: 7 2 2019
Statut: ppublish

Résumé

To examine the association between metabolic deregulation and pancreatic cancer, we conducted a two-stage case-control targeted metabolomics study using prediagnostic sera collected one year before diagnosis in the Women's Health Initiative study. We used the LC/MS to quantitate 470 metabolites in 30 matched case/control pairs. From 180 detectable metabolites, we selected 14 metabolites to be validated in additional 18 matched case/control pairs. We used the paired

Identifiants

DOI: 10.1158/1940-6207.CAPR-18-0201 PMID: 30723176 PMC: PMC6445762
pubmed: 30723176
pii: 1940-6207.CAPR-18-0201
doi: 10.1158/1940-6207.CAPR-18-0201
pmc: PMC6445762
mid: NIHMS1520874
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

237-246

Subventions

Organisme : HSRD VA
ID : I50 HX001236
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA172880
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH42129
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01WH32118
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH32108
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH32100
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH22110
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH24152
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01WH42107
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA220297
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH32119
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01WH32105
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH32111
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH32115
Pays : United States
Organisme : WHI NIH HHS
ID : N01WH44221
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Li Jiao (L)

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas. jiao@bcm.edu.
Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, Texas.
Advanced Technology Core, Baylor College of Medicine, Houston, Texas.
Department of Molecular & Cell Biology, Baylor College of Medicine, Houston, Texas.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Suman Maity (S)

Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.

Cristian Coarfa (C)

Advanced Technology Core, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0002-4183-4939

Kimal Rajapakshe (K)

Texas Medical Center Digestive Disease Center, Houston, Texas.

Liang Chen (L)

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, Texas.

Feng Jin (F)

Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.

Vasanta Putluri (V)

Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.

Lesley F Tinker (LF)

Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas.

Qianxing Mo (Q)

Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.

Fengju Chen (F)

Advanced Technology Core, Baylor College of Medicine, Houston, Texas.

Subrata Sen (S)

Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Haleh Sangi-Hyghpeykar (H)

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Hashem B El-Serag (HB)

Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, Texas.
Advanced Technology Core, Baylor College of Medicine, Houston, Texas.
Department of Molecular & Cell Biology, Baylor College of Medicine, Houston, Texas.
ORCID: 0000-0001-5964-7579

Nagireddy Putluri (N)

Advanced Technology Core, Baylor College of Medicine, Houston, Texas.
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Texas Medical Center Digestive Disease Center, Houston, Texas.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Métabolisme › Métabolome › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Post-ménopause › A Prospective Targeted Serum Metabolomics...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › A Prospective Targeted Serum Metabolomics...