Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma.

B cells head and neck squamous cell carcinoma humoral immune response tertiary lymphoid structures tumor microenvironment tumor-associated antigens

Journal

Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526

Informations de publication

Date de publication:
Historique:
received: 09 02 2018
revised: 07 10 2018
accepted: 09 10 2018
entrez: 7 2 2019
pubmed: 7 2 2019
medline: 7 2 2019
Statut: epublish

Résumé

B lymphocytes are important players in immune responses to cancer. However, their composition and function in head and neck squamous cell carcinoma (HNSCC) has not been well described. Here, we analyzed B cell subsets in HNSCC (n = 38), non-cancerous mucosa (n = 14) and peripheral blood from HNSCC patients (n = 38) and healthy controls (n = 20) by flow cytometry. Intratumoral B cells contained high percentages of activated (CD86

Identifiants

pubmed: 30723574
doi: 10.1080/2162402X.2018.1535293
pii: 1535293
pmc: PMC6350680
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

1535293

Références

Immunology. 2011 Dec;134(4):361-7
pubmed: 22043829
Blood. 2011 Jul 14;118(2):348-57
pubmed: 21551230
Cancer Res. 2013 Apr 15;73(8):2468-79
pubmed: 23384943
Genome Biol. 2004;5(10):R80
pubmed: 15461798
Mol Cancer Ther. 2015 Mar;14(3):828-34
pubmed: 25564441
Oncotarget. 2017 Jul 21;8(42):72108-72126
pubmed: 29069772
Int J Cancer. 2008 Dec 1;123(11):2626-31
pubmed: 18785210
Autoimmun Rev. 2012 Jul;11(9):670-7
pubmed: 22155204
N Engl J Med. 2016 Nov 10;375(19):1856-1867
pubmed: 27718784
Immunotargets Ther. 2015 Aug 05;4:159-71
pubmed: 27471721
PLoS Comput Biol. 2013;9(8):e1003118
pubmed: 23950696
Nature. 2015 Jan 29;517(7536):576-82
pubmed: 25631445
PLoS One. 2013 Oct 10;8(10):e77025
pubmed: 24130830
Fam Cancer. 2011 Sep;10(3):557-65
pubmed: 21598004
Science. 2011 Aug 26;333(6046):1157-60
pubmed: 21798893
Trends Cancer. 2016 Dec;2(12):747-757
pubmed: 28626801
BMC Cancer. 2009 Aug 22;9:292
pubmed: 19698134
Oral Oncol. 2016 Feb;53:27-35
pubmed: 26631955
Int J Cancer. 2013 Jan 1;132(1):72-81
pubmed: 22592660
Br J Cancer. 2015 Nov 3;113(9):1343-9
pubmed: 26461054
Oncoimmunology. 2015 Jan 30;4(1):e965570
pubmed: 25949860
Oral Oncol. 2015 Aug;51(8):727-30
pubmed: 26066977
Br J Cancer. 2013 Nov 12;109(10):2629-35
pubmed: 24169351
Oncoimmunology. 2013 Jul 1;2(7):e25443
pubmed: 24073382
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cancer Biol Ther. 2006 Sep;5(9):1218-25
pubmed: 16929165
Head Neck. 2016 Jul;38(7):1074-84
pubmed: 26879675
Oncoimmunology. 2015 Jun 3;5(2):e1054598
pubmed: 27057426
BMC Clin Pathol. 2014 Aug 23;14:38
pubmed: 25177210
Immunity. 2010 Jan 29;32(1):129-40
pubmed: 20079667
Oncotarget. 2017 Jul 4;8(27):44418-44433
pubmed: 28574843
J Leukoc Biol. 2017 Feb;101(2):577-587
pubmed: 27534894
Cancer Immunol Immunother. 2011 Dec;60(12):1729-38
pubmed: 21779876
Immunity. 2015 Apr 21;42(4):607-12
pubmed: 25902480
Methods Mol Biol. 2012;900:109-34
pubmed: 22933067
J Invest Dermatol. 2000 Jul;115(1):124-8
pubmed: 10886519
Oral Oncol. 2009 Oct;45(10):e167-74
pubmed: 19576838
Cancer Cell. 2010 Feb 17;17(2):121-34
pubmed: 20138013
Clin Cancer Res. 2008 Aug 15;14(16):5220-7
pubmed: 18698040
J Ovarian Res. 2016 Apr 06;9:21
pubmed: 27048364
J Exp Med. 2015 Feb 9;212(2):217-33
pubmed: 25646266
Cancer Cell. 2014 Jun 16;25(6):809-821
pubmed: 24909985
Int J Cancer. 2016 Sep 1;139(5):1129-39
pubmed: 27074317
Int J Cancer. 2014 Sep 1;135(5):1142-52
pubmed: 24482145
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Front Immunol. 2018 Mar 23;9:493
pubmed: 29628923
Head Neck Oncol. 2013 Feb 27;5(3):24
pubmed: 24723971
Cancer Lett. 2013 Jun 10;333(2):222-8
pubmed: 23370224
Nat Biotechnol. 2013 Feb;31(2):166-9
pubmed: 23334449
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):701-9
pubmed: 16467079
Oral Oncol. 2017 Jul;70:43-50
pubmed: 28622890
Cancer Immunol Res. 2017 Sep;5(9):730-743
pubmed: 28778961
Am J Respir Crit Care Med. 2014 Apr 1;189(7):832-44
pubmed: 24484236
Front Immunol. 2016 Oct 03;7:407
pubmed: 27752258
Am J Respir Crit Care Med. 2016 Dec 1;194(11):1403-1412
pubmed: 27299180
Oncoimmunology. 2013 Dec 1;2(12):e26836
pubmed: 24498556
Nat Immunol. 2010 Jun;11(6):535-42
pubmed: 20453843
Front Immunol. 2012 Oct 10;3:302
pubmed: 23087687
Immunity. 2004 Sep;21(3):401-13
pubmed: 15357951

Auteurs

Axel Lechner (A)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig Maximilians University, Munich, Germany.
Gene Center, Ludwig Maximilians University, Munich, Germany.

Hans A Schlößer (HA)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.

Martin Thelen (M)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Department I of Internal Medicine, Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.

Kerstin Wennhold (K)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Department I of Internal Medicine, Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.

Sacha I Rothschild (SI)

Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland.

Ramona Gilles (R)

Institute of Transfusion Medicine, University of Cologne, Cologne, Germany.

Alexander Quaas (A)

Institute of Pathology, University of Cologne, Cologne, Germany.

Oliver G Siefer (OG)

Jean-Uhrmacher-Institute for Clinical ENT Research, University of Cologne, Cologne, Germany.

Christian U Huebbers (CU)

Jean-Uhrmacher-Institute for Clinical ENT Research, University of Cologne, Cologne, Germany.

Engin Cukuroglu (E)

Computational and Systems Biology, Genome Institute of Singapore, Singapore.

Jonathan Göke (J)

Computational and Systems Biology, Genome Institute of Singapore, Singapore.
National Cancer Centre, Singapore.

Axel Hillmer (A)

Institute of Pathology, University of Cologne, Cologne, Germany.

Birgit Gathof (B)

Institute of Transfusion Medicine, University of Cologne, Cologne, Germany.

Moritz F Meyer (MF)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.

Jens P Klussmann (JP)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.

Alexander Shimabukuro-Vornhagen (A)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Department I of Internal Medicine, Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.

Sebastian Theurich (S)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Gene Center, Ludwig Maximilians University, Munich, Germany.
Department I of Internal Medicine, Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Cancer- and Immunometabolism Research Group, Dept. I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Department of Medicine III, University Hospital, LMU Munich, Germany.

Dirk Beutner (D)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Georg August University, Goettingen, Germany.

Michael von Bergwelt-Baildon (M)

Cologne Interventional Immunology, Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Department of Medicine III, University Hospital, LMU Munich, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Georg August University, Goettingen, Germany.
Partner Site, German Cancer Consortium (DKTK), Munich, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Classifications MeSH