Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues.

Cell Line, Tumor Drug Carriers / chemistry Gene Knockdown Techniques / methods Guanidines / chemistry Humans Nanostructures / chemistry RNA Interference / physiology RNA, Small Interfering / metabolism Spheroids, Cellular / physiology Transcytosis / physiology Transferrin / chemistry

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
20 02 2019
Historique:
pubmed: 7 2 2019
medline: 8 7 2020
entrez: 7 2 2019
Statut: ppublish

Résumé

Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/exocytosis event. We developed a Tf-appended nanocaplet (

Identifiants

DOI: 10.1021/jacs.8b12501 PMID: 30724083
pubmed: 30724083
doi: 10.1021/jacs.8b12501
doi:

Substances chimiques

Drug Carriers 0
Guanidines 0
RNA, Small Interfering 0
Transferrin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2862-2866

Auteurs

Ai Kohata (A)

Department of Chemistry and Biotechnology, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.

P K Hashim (PK)

Department of Chemistry and Biotechnology, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.

Kou Okuro (K)

Department of Chemistry and Biotechnology, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.
ORCID: 0000-0003-0445-6358

Takuzo Aida (T)

Department of Chemistry and Biotechnology, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku , Tokyo 113-8656 , Japan.
Riken Center for Emergent Matter Science , 2-1 Hirosawa , Wako , Saitama 351-0198 , Japan.
ORCID: 0000-0002-0002-8017

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Cellules › Cellules cultivées › Sphéroïdes de cellules › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Transcytose › Transferrin-Appended Nanocaplet for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Transferrines › Transferrine › Transferrin-Appended Nanocaplet for...