Fourth generation e-cigarette vaping induces transient lung inflammation and gas exchange disturbances: results from two randomized clinical trials.
arterial oxygen tension
club cell protein-16
e-cigarette
transcutaneous oxygen tension
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
pubmed:
7
2
2019
medline:
12
2
2020
entrez:
7
2
2019
Statut:
ppublish
Résumé
When heated by an electronic cigarette, propylene glycol and glycerol produce a nicotine-carrying-aerosol. This hygroscopic/hyperosmolar aerosol can deposit deep within the lung. Whether these deposits trigger local inflammation and disturb pulmonary gas exchanges is not known. The aim of this study was to assess the acute effects of high-wattage electronic cigarette vaping with or without nicotine on lung inflammation biomarkers, transcutaneous gas tensions, and pulmonary function tests in young and healthy tobacco smokers. Acute effects of vaping without nicotine on arterial blood gas tensions were also assessed in heavy smokers suspected of coronary artery disease. Using a single-blind within-subjects study design, 25 young tobacco smokers underwent three experimental sessions in random order: sham-vaping and vaping with and without nicotine at 60 W. Twenty heavy smokers were also exposed to sham-vaping (
Identifiants
pubmed: 30724099
doi: 10.1152/ajplung.00492.2018
pmc: PMC6589591
doi:
Substances chimiques
SCGB1A1 protein, human
0
Nicotine
6M3C89ZY6R
Uteroglobin
9060-09-7
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L705-L719Commentaires et corrections
Type : CommentIn
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