Mechanism of Acetic Acid Gustatory Repulsion in Drosophila.
Drosophila
acid taste
feeding
labeled line
proton
sour
sourness
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
26
03
2018
revised:
07
11
2018
accepted:
10
01
2019
entrez:
7
2
2019
pubmed:
7
2
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
The decision to consume or reject a food based on the degree of acidity is critical for animal survival. However, the gustatory receptors that detect sour compounds and influence feeding behavior have been elusive. Here, using the fly, Drosophila melanogaster, we reveal that a member of the ionotropic receptor family, IR7a, is essential for rejecting foods laced with high levels of acetic acid. IR7a is dispensable for repulsion of other acidic compounds, indicating that the gustatory sensation of acids occurs through a repertoire rather than a single receptor. The fly's main taste organ, the labellum, is decorated with bristles that house dendrites of gustatory receptor neurons (GRNs). IR7a is expressed in a subset of bitter GRNs rather than GRNs dedicated to sour taste. Our findings indicate that flies taste acids through a repertoire of receptors, enabling them to discriminate foods on the basis of acid composition rather than just pH.
Identifiants
pubmed: 30726729
pii: S2211-1247(19)30060-9
doi: 10.1016/j.celrep.2019.01.042
pmc: PMC6490183
mid: NIHMS1021660
pii:
doi:
Substances chimiques
Acids
0
Drosophila Proteins
0
Receptors, Ionotropic Glutamate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1432-1442.e4Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC007864
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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