Serum Cadmium Level Is Positively Associated with Unruptured Intracranial Aneurysm Incidence.
Cadmium
Incidence
Intracranial Aneurysm
Serum
Smoking
Journal
Korean journal of family medicine
ISSN: 2005-6443
Titre abrégé: Korean J Fam Med
Pays: Korea (South)
ID NLM: 101502902
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
19
12
2017
accepted:
01
03
2018
pubmed:
8
2
2019
medline:
8
2
2019
entrez:
8
2
2019
Statut:
ppublish
Résumé
Cadmium is a toxic element in cigarette smoke associated with ischemic vascular disease. Its association with cerebral aneurysm is unknown. We retrospectively analyzed the medical records of patients with headache who underwent imaging studies between March 2014 and August 2016. An unruptured intracranial aneurysm (UIA) was confirmed by brain magnetic resonance angiography or computed tomography angiography. A control group included age- and sexmatched patients without an UIA. Whole blood and random urine tests were used for detection of cadmium and arsenic levels, respectively. Student t-test was used to compare subject characteristics, mean cadmium and arsenic levels between groups, and differences between groups with small (<4-mm) and large (≥4-mm) UIAs. Multivariate regression analysis was used to identify risk factors for aneurysm incidence. Of 238 patients, 25 had an UIA. Those with an UIA had more pack-years of smoking (19.5±3.8 vs. 12.5±6.8, P=0.044) and higher mean serum cadmium levels (1.77±0.19 vs. 0.87±0.21 µg/L, P=0.027). Arsenic levels showed no difference between groups. (67.4±23.5 vs. 62.2±18.3 µg/L, P=0.458). There were no significantly different demographic, clinical, or laboratory characteristics between small and large aneurysm groups. According to multivariate analysis, smoking (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.06-2.33; P=0.047) and serum cadmium >2.0 mcg/L (OR, 1.39; 95% CI, 1.15-1.84; P=0.043) were associated with aneurysm incidence. UIA incidence was associated with pack-years of smoking and serum cadmium level, but aneurysm size was not associated with serum cadmium level.
Sections du résumé
BACKGROUND
BACKGROUND
Cadmium is a toxic element in cigarette smoke associated with ischemic vascular disease. Its association with cerebral aneurysm is unknown.
METHODS
METHODS
We retrospectively analyzed the medical records of patients with headache who underwent imaging studies between March 2014 and August 2016. An unruptured intracranial aneurysm (UIA) was confirmed by brain magnetic resonance angiography or computed tomography angiography. A control group included age- and sexmatched patients without an UIA. Whole blood and random urine tests were used for detection of cadmium and arsenic levels, respectively. Student t-test was used to compare subject characteristics, mean cadmium and arsenic levels between groups, and differences between groups with small (<4-mm) and large (≥4-mm) UIAs. Multivariate regression analysis was used to identify risk factors for aneurysm incidence.
RESULTS
RESULTS
Of 238 patients, 25 had an UIA. Those with an UIA had more pack-years of smoking (19.5±3.8 vs. 12.5±6.8, P=0.044) and higher mean serum cadmium levels (1.77±0.19 vs. 0.87±0.21 µg/L, P=0.027). Arsenic levels showed no difference between groups. (67.4±23.5 vs. 62.2±18.3 µg/L, P=0.458). There were no significantly different demographic, clinical, or laboratory characteristics between small and large aneurysm groups. According to multivariate analysis, smoking (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.06-2.33; P=0.047) and serum cadmium >2.0 mcg/L (OR, 1.39; 95% CI, 1.15-1.84; P=0.043) were associated with aneurysm incidence.
CONCLUSION
CONCLUSIONS
UIA incidence was associated with pack-years of smoking and serum cadmium level, but aneurysm size was not associated with serum cadmium level.
Identifiants
pubmed: 30727706
pii: kjfm.17.0140
doi: 10.4082/kjfm.17.0140
pmc: PMC6669382
doi:
Types de publication
Journal Article
Langues
eng
Pagination
273-277Références
No Shinkei Geka. 1999 Sep;27(9):831-5
pubmed: 10478344
Toxicol Appl Pharmacol. 2002 Mar 1;179(2):83-8
pubmed: 11884240
J Korean Neurosurg Soc. 2009 Jan;45(1):11-5
pubmed: 19242565
J Pharmacol Sci. 2009 Jul;110(3):405-9
pubmed: 19609071
Environ Res. 2010 Feb;110(2):199-206
pubmed: 20060521
Stroke. 2010 May;41(5):916-20
pubmed: 20378866
Circ J. 2011;75(10):2491-5
pubmed: 21799275
Mediators Inflamm. 2012;2012:271582
pubmed: 23316103
Stroke. 2013 Apr;44(4):984-7
pubmed: 23422088
Stroke. 2013 Sep;44(9):2414-21
pubmed: 23868274
Oxid Med Cell Longev. 2013;2013:898034
pubmed: 23997854
Neurosurgery. 2015 Jul;77(1):59-66; discussion 66
pubmed: 25839377
Stroke. 2016 Feb;47(2):365-71
pubmed: 26742803
Atherosclerosis. 2016 Jun;249:230-2
pubmed: 27012656
J Neurosurg. 2017 Oct;127(4):748-753
pubmed: 27911237
Stroke. 1997 Sep;28(9):1717-23
pubmed: 9303014