Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory.
Animals
Anxiety
/ genetics
Aromatase
/ genetics
Cognition
Dendritic Spines
Estradiol
/ metabolism
Female
Hippocampus
Long-Term Potentiation
/ genetics
Male
Memory
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuronal Plasticity
/ physiology
Neurons
/ physiology
Prosencephalon
/ enzymology
Psychomotor Performance
/ physiology
Spatial Learning
Synapses
/ physiology
aromatase
cerebral cortex
cognition
estrogen
hippocampus
synapse
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
10 04 2019
10 04 2019
Historique:
received:
01
08
2018
revised:
28
12
2018
accepted:
18
01
2019
pubmed:
8
2
2019
medline:
17
6
2020
entrez:
8
2
2019
Statut:
ppublish
Résumé
17β-estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2 is known to be made in neurons in the brain, but its precise functions in the brain are unclear. Here, we used a forebrain-neuron-specific aromatase knock-out (FBN-ARO-KO) mouse model to deplete neuron-derived E2 in the forebrain of mice and thereby elucidate its functions. FBN-ARO-KO mice showed a 70-80% decrease in aromatase and forebrain E2 levels compared with FLOX controls. Male and female FBN-ARO-KO mice exhibited significant deficits in forebrain spine and synaptic density, as well as hippocampal-dependent spatial reference memory, recognition memory, and contextual fear memory, but had normal locomotor function and anxiety levels. Reinstating forebrain E2 levels via exogenous
Identifiants
pubmed: 30728170
pii: JNEUROSCI.1970-18.2019
doi: 10.1523/JNEUROSCI.1970-18.2019
pmc: PMC6462452
doi:
Substances chimiques
Estradiol
4TI98Z838E
Aromatase
EC 1.14.14.1
Cyp19a1 protein, mouse
EC 1.14.14.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2792-2809Subventions
Organisme : BLRD VA
ID : I01 BX003195
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088058
Pays : United States
Informations de copyright
Copyright © 2019 Lu, Sareddy et al.
Références
Nature. 1999 Nov 25;402(6760):421-5
pubmed: 10586883
J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):237-41
pubmed: 10622413
J Neurochem. 2001 Jan;76(1):1-10
pubmed: 11145972
J Neuroendocrinol. 2001 Apr;13(4):317-23
pubmed: 11264718
Annu Rev Neurosci. 2001;24:1071-89
pubmed: 11520928
J Neurosci. 2002 Mar 1;22(5):1532-40
pubmed: 11880483
Neuron. 2002 Aug 15;35(4):605-23
pubmed: 12194863
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70
pubmed: 14694190
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2185-90
pubmed: 14766964
Horm Behav. 2004 Apr;45(4):250-8
pubmed: 15053941
J Neurosci. 2004 Jun 30;24(26):5913-21
pubmed: 15229239
J Neurosci. 2004 Sep 8;24(36):7958-63
pubmed: 15356210
Neuroscience. 2005;136(3):833-42
pubmed: 16344155
J Neurosci. 2006 Apr 12;26(15):4104-10
pubmed: 16611827
Rev Neurosci. 2006;17(6):619-34
pubmed: 17283607
Steroids. 2007 May;72(5):381-405
pubmed: 17379265
Menopause. 2007 Nov-Dec;14(6):995-8
pubmed: 17898668
Neurobiol Learn Mem. 2008 Mar;89(3):312-23
pubmed: 17942328
Neurosignals. 2008;16(2-3):140-53
pubmed: 18253054
Nat Neurosci. 2008 Mar;11(3):334-43
pubmed: 18297067
Brain Res. 2008 May 13;1209:115-27
pubmed: 18402929
Brain Res. 2010 Feb 22;1315:41-52
pubmed: 19815003
Endocrinology. 2010 Mar;151(3):1153-60
pubmed: 20097718
Breast Cancer Res Treat. 2011 Feb;126(1):221-6
pubmed: 21046229
Endocr Rev. 2011 Aug;32(4):532-49
pubmed: 21622487
J Neurosci. 1990 Jun;10(6):1788-98
pubmed: 2162385
Neuroendocrinology. 2012;96(2):119-30
pubmed: 22538356
J Neurosci. 2012 Jun 13;32(24):8116-26
pubmed: 22699893
Neuropsychopharmacology. 2012 Nov;37(12):2615-23
pubmed: 22781845
Neuroscience. 2013 Jun 3;239:34-45
pubmed: 23079626
Steroids. 2013 Jun;78(6):614-23
pubmed: 23276632
PLoS Biol. 2013;11(2):e1001478
pubmed: 23424281
Neuropharmacology. 2014 Jan;76 Pt C:639-56
pubmed: 23602987
Clin Breast Cancer. 2014 Apr;14(2):132-40
pubmed: 24291380
Mol Cell Endocrinol. 2014 May 25;389(1-2):84-91
pubmed: 24508637
J Physiol. 2015 Feb 15;593(4):871-86
pubmed: 25504573
Brain Res. 2015 Sep 24;1621:147-61
pubmed: 25595055
Mol Cell Biol. 2015 May;35(9):1557-72
pubmed: 25713104
Psychoneuroendocrinology. 2015 Jun;56:213-25
pubmed: 25863445
Breast Cancer Res Treat. 2015 Aug;152(3):569-80
pubmed: 26160250
Front Cell Neurosci. 2015 Oct 02;9:376
pubmed: 26483631
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6673-82
pubmed: 26627258
Hippocampus. 2016 Mar;26(3):275-81
pubmed: 26663094
Horm Behav. 2016 Jul;83:60-67
pubmed: 27178577
Mol Neurobiol. 2017 Aug;54(6):4551-4559
pubmed: 27379735
Neurobiol Aging. 2017 Jan;49:165-182
pubmed: 27815990
J Alzheimers Dis. 2017;56(4):1469-1484
pubmed: 28157094
Endocrinology. 2017 Apr 1;158(4):852-859
pubmed: 28324066
Neuroscience. 2017 Nov 5;363:11-25
pubmed: 28888955
Pharmacol Rep. 2017 Dec;69(6):1300-1307
pubmed: 29128813
Elife. 2017 Nov 27;6:
pubmed: 29173281
Breast Cancer Res Treat. 2018 Apr;168(2):299-310
pubmed: 29264751
J Steroid Biochem Mol Biol. 2018 Apr;178:354-368
pubmed: 29452160
Biol Reprod. 1981 May;24(4):784-94
pubmed: 7195743
Brain Res Bull. 1981 Aug;7(2):113-20
pubmed: 7272792
Brain Res Bull. 1981 Aug;7(2):121-30
pubmed: 7272793
Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8856-60
pubmed: 7568031
J Comp Neurol. 1979 Jun 1;185(3):423-59
pubmed: 86549
Cell. 1996 Dec 27;87(7):1317-26
pubmed: 8980237
J Physiol Paris. 1996;90(3-4):157-64
pubmed: 9116659
Neuron. 1998 Apr;20(4):709-26
pubmed: 9581763
Pathol Biol (Paris). 1998 Nov;46(9):699-700
pubmed: 9885822