Structure-function characterization of an insecticidal protein GNIP1Aa, a member of an MACPF and β-tripod families.
Amino Acid Sequence
/ genetics
Animals
Bacterial Proteins
/ chemistry
Chromobacterium
/ chemistry
Coleoptera
/ genetics
Complement Membrane Attack Complex
/ chemistry
Crystallography, X-Ray
Insecticides
/ chemistry
Models, Molecular
Perforin
/ chemistry
Pore Forming Cytotoxic Proteins
/ chemistry
Protein Domains
Protein Structure, Tertiary
MACPF
crystal structure
insecticidal protein
protein family
β-tripod domain
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 02 2019
19 02 2019
Historique:
pubmed:
8
2
2019
medline:
3
5
2019
entrez:
8
2
2019
Statut:
ppublish
Résumé
The crystal structure of the Gram-negative insecticidal protein, GNIP1Aa, has been solved at 2.5-Å resolution. The protein consists of two structurally distinct domains, a MACPF (membrane attack complex/PerForin) and a previously uncharacterized type of domain. GNIP1Aa is unique in being a prokaryotic MACPF member to have both its structure and function identified. It was isolated from a
Identifiants
pubmed: 30728296
pii: 1815547116
doi: 10.1073/pnas.1815547116
pmc: PMC6386698
doi:
Substances chimiques
Bacterial Proteins
0
Complement Membrane Attack Complex
0
Insecticides
0
Pore Forming Cytotoxic Proteins
0
Perforin
126465-35-8
Banques de données
PDB
['6FBM']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2897-2906Déclaration de conflit d'intérêts
Conflict of interest statement: J.Z., D.V., and S.L.M. are current employees of BASF; J.F., J.D., C.K., and D.B. are current employees of Bayer; N.B.D. was formerly employed by Bayer. GNIP1Aa is protected under US Patent 8575425 and family members, and US Patent 9862965 and family members.
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