Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults.
Aged
Alcohol Drinking
/ adverse effects
Brain
/ diagnostic imaging
Brain Mapping
Exercise
Female
Genetic Predisposition to Disease
/ genetics
Health Behavior
Humans
Imaging, Three-Dimensional
Life Style
Lymphocytes
Magnetic Resonance Imaging
/ methods
Male
Prefrontal Cortex
/ pathology
Risk Factors
Sensorimotor Cortex
Smoking
/ adverse effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 02 2019
06 02 2019
Historique:
received:
02
02
2018
accepted:
12
01
2019
revised:
02
01
2019
entrez:
8
2
2019
pubmed:
8
2
2019
medline:
12
4
2019
Statut:
epublish
Résumé
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.
Identifiants
pubmed: 30728360
doi: 10.1038/s41467-019-08500-x
pii: 10.1038/s41467-019-08500-x
pmc: PMC6365564
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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