pAKT pathway activation is associated with
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
05
2018
accepted:
08
01
2019
entrez:
8
2
2019
pubmed:
8
2
2019
medline:
8
2
2019
Statut:
epublish
Résumé
Numerous studies have focused on the PI3K/AKT/mTOR pathway in estrogen receptor positive (ER) breast cancer (BC), as a linear signal transduction pathway and reported its association with worse clinical outcomes. We developed gene signatures that reflect the level of expression of phosphorylated-Serine473-AKT (pAKT) and phosphorylated-Serine2448-mTOR (p-mTOR) separately, capturing their corresponding level of pathway activation. Our analysis revealed that the pAKT pathway activation was associated with luminal A BC while the p-mTOR pathway activation was more associated with luminal B BC (Kruskal-Wallis test
Identifiants
pubmed: 30729154
doi: 10.1038/s41523-019-0102-1
pii: 102
pmc: PMC6355773
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Biochem J. 1999 Dec 1;344 Pt 2:427-31
pubmed: 10567225
Cancer Res. 2000 Jul 1;60(13):3504-13
pubmed: 10910062
Nature. 2002 Jan 31;415(6871):530-6
pubmed: 11823860
Nucleic Acids Res. 2002 Apr 1;30(7):1575-84
pubmed: 11917018
N Engl J Med. 2002 Dec 19;347(25):1999-2009
pubmed: 12490681
Lancet. 2003 May 10;361(9369):1590-6
pubmed: 12747878
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
pubmed: 12829800
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8
pubmed: 12917485
Cancer Res. 2003 Nov 1;63(21):7167-75
pubmed: 14612510
Science. 2004 Apr 23;304(5670):554
pubmed: 15016963
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94
pubmed: 15342917
Cancer Res. 2004 Nov 1;64(21):7678-81
pubmed: 15520168
Lancet. 2005 Feb 19-25;365(9460):671-9
pubmed: 15721472
Cell. 2005 Apr 22;121(2):179-93
pubmed: 15851026
Oncogene. 2005 Jul 7;24(29):4660-71
pubmed: 15897907
J Biol Chem. 2005 Jul 8;280(27):25485-90
pubmed: 15899889
Nature. 2005 Jul 28;436(7050):518-24
pubmed: 16049480
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13550-5
pubmed: 16141321
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2006 Jan 19;439(7074):353-7
pubmed: 16273092
Breast Cancer Res. 2005;7(6):R953-64
pubmed: 16280042
Nat Rev Drug Discov. 2005 Dec;4(12):988-1004
pubmed: 16341064
Cancer Cell. 2006 Feb;9(2):121-32
pubmed: 16473279
J Natl Cancer Inst. 2006 Feb 15;98(4):262-72
pubmed: 16478745
Nature. 2006 May 25;441(7092):523-7
pubmed: 16680151
J Clin Oncol. 2006 Sep 10;24(26):4236-44
pubmed: 16896004
Nature. 2006 Aug 17;442(7104):779-85
pubmed: 16915281
Cancer Cell. 2006 Dec;10(6):529-41
pubmed: 17157792
J Clin Oncol. 2007 Apr 1;25(10):1239-46
pubmed: 17401012
Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6740-5
pubmed: 17420468
BMC Cancer. 2007 Apr 11;7:61
pubmed: 17428335
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9
pubmed: 17452630
Clin Cancer Res. 2007 Jun 1;13(11):3207-14
pubmed: 17545524
Cell. 2007 Jun 29;129(7):1261-74
pubmed: 17604717
Cancer Cell. 2007 Jul;12(1):9-22
pubmed: 17613433
Breast Cancer Res Treat. 2008 Jun;109(3):491-501
pubmed: 17659439
Lancet Oncol. 2007 Dec;8(12):1071-1078
pubmed: 18024211
J Clin Oncol. 2008 Mar 10;26(8):1275-81
pubmed: 18250347
Breast Cancer Res Treat. 2008 Mar;108(2):191-201
pubmed: 18297396
Breast Cancer Res. 2008;10(2):R34
pubmed: 18430221
BMC Genomics. 2008 May 22;9:239
pubmed: 18498629
Breast Cancer Res Treat. 2009 Jul;116(1):69-77
pubmed: 18592372
Cancer Res. 2008 Jul 1;68(13):5405-13
pubmed: 18593943
PLoS Genet. 2008 Jul 18;4(7):e1000129
pubmed: 18636107
Breast Cancer Res Treat. 2009 Jul;116(2):303-9
pubmed: 18821012
Nature. 2009 Jun 18;459(7249):1005-9
pubmed: 19421193
Clin Cancer Res. 2009 Aug 15;15(16):5049-59
pubmed: 19671852
Breast Cancer Res Treat. 2010 Jun;121(3):575-89
pubmed: 19688261
Breast Cancer Res Treat. 2010 Oct;123(3):661-77
pubmed: 19960244
Breast Cancer Res. 2010;12(1):R5
pubmed: 20064235
J Clin Oncol. 2010 Mar 1;28(7):1145-53
pubmed: 20100965
Breast Cancer Res. 2010;12(2):R21
pubmed: 20346151
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10208-13
pubmed: 20479250
Breast Cancer Res Treat. 2010 Jul;122(2):419-28
pubmed: 20480226
J Clin Oncol. 2010 Sep 20;28(27):4111-9
pubmed: 20697068
Breast Cancer Res. 2010;12(5):R68
pubmed: 20813035
PLoS One. 2010 Dec 01;5(12):e15031
pubmed: 21152022
EMBO Mol Med. 2011 Dec;3(12):726-41
pubmed: 21910250
N Engl J Med. 2012 Feb 9;366(6):520-9
pubmed: 22149876
Nature. 2012 Apr 18;486(7403):346-52
pubmed: 22522925
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Mol Cancer Ther. 2014 May;13(5):1021-31
pubmed: 24748656
Cancer Treat Rev. 2016 Apr;45:87-96
pubmed: 26995633
Cancer Cell. 2016 Aug 8;30(2):229-242
pubmed: 27451907
Int J Oncol. 2018 Feb;52(2):424-432
pubmed: 29207087
J Biol Chem. 1997 Nov 21;272(47):29911-8
pubmed: 9368067