Regional protein expression in human Alzheimer's brain correlates with disease severity.
Aged
Aged, 80 and over
Alzheimer Disease
/ genetics
Autopsy
Case-Control Studies
Cerebellum
/ metabolism
Disease Progression
Entorhinal Cortex
/ metabolism
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Gyrus Cinguli
/ metabolism
Hippocampus
/ metabolism
Humans
Male
Middle Aged
Motor Cortex
/ metabolism
Nerve Tissue Proteins
/ classification
Organ Specificity
Signal Transduction
Somatosensory Cortex
/ metabolism
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
05
2018
accepted:
03
12
2018
entrez:
8
2
2019
pubmed:
8
2
2019
medline:
8
2
2019
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial scope of the study of AD and prioritise the study of human brains. Here we show that functionally distinct human brain regions display varying and region-specific changes in protein expression. These changes provide insights into the progression of disease, novel AD-related pathways, the presence of a gradient of protein expression change from less to more affected regions and a possibly protective protein expression profile in the cerebellum. This spatial proteomics analysis provides a framework which can underpin current research and open new avenues to enhance molecular understanding of AD pathophysiology, provide new targets for intervention and broaden the conceptual frameworks for future AD research.
Identifiants
pubmed: 30729181
doi: 10.1038/s42003-018-0254-9
pii: 254
pmc: PMC6361956
doi:
Substances chimiques
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
43Subventions
Organisme : Medical Research Council
ID : MR/L011093/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L011093/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L011093/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N028457/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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