Bile cytology: A new scoring system for improving diagnostic accuracy.
aspiration, bile, cytology, diagnosis, scoring system
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
17
10
2017
revised:
16
07
2018
accepted:
20
08
2018
pubmed:
8
2
2019
medline:
22
11
2019
entrez:
8
2
2019
Statut:
ppublish
Résumé
Benign and malignant cells need to be distinguished in any cytological examination of bile. Here, we report an original scoring system to improve the diagnostic accuracy of bile cytology. The study used 158 bile aspiration samples obtained for cytological examination. Fourteen cytological findings were used to differentiate benign and malignant samples. Statistical significance tests and multivariate analysis were used to determine and quantify significant findings and develop a scoring system. Four cytological findings were significant in discriminating between benign and malignant cells: abnormal chromatin, irregularly arranged nuclei, irregularly overlapped nuclei, and irregular cluster margins. Our newly developed scoring system based on these four cytological findings yielded excellent results with a sensitivity of 87%, specificity of 98%, and an odds ratio of 329. The use of our new scoring system is expected to contribute to the diagnostic accuracy of cytological evaluations of bile samples.
Sections du résumé
BACKGROUND
BACKGROUND
Benign and malignant cells need to be distinguished in any cytological examination of bile. Here, we report an original scoring system to improve the diagnostic accuracy of bile cytology.
METHODS
METHODS
The study used 158 bile aspiration samples obtained for cytological examination. Fourteen cytological findings were used to differentiate benign and malignant samples. Statistical significance tests and multivariate analysis were used to determine and quantify significant findings and develop a scoring system.
RESULTS
RESULTS
Four cytological findings were significant in discriminating between benign and malignant cells: abnormal chromatin, irregularly arranged nuclei, irregularly overlapped nuclei, and irregular cluster margins. Our newly developed scoring system based on these four cytological findings yielded excellent results with a sensitivity of 87%, specificity of 98%, and an odds ratio of 329.
CONCLUSIONS
CONCLUSIONS
The use of our new scoring system is expected to contribute to the diagnostic accuracy of cytological evaluations of bile samples.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-647Informations de copyright
© 2019 Wiley Periodicals, Inc.